日本血吸虫病肝纤维化的危险因素探讨

STUDIES ON RISK FACTORS FOR LIVER FIBROSIS OF SCHISTOSOMIASIS JAPONICA

[目的 ]探讨日本血吸虫病患者肝纤维化的影响因素。 [方法 ]日本血吸虫病 2级和 3级肝纤维化患者 81例 ,1级肝纤维化患者 6 1例和无肝纤维化的血吸虫感染者 5 0例 ,就可能影响肝脏损伤的因素进行研究 ,对所有因素用有序回归模型分析。 [结果 ]可能与日本血吸虫病肝纤维化有关的危险因素有 :血吸虫病治疗次数(OR =1 75 ) ,血吸虫感染间期 (OR =1 40 ) ) ,经常饮酒 (每天多于 1次 ,5年以上 ) (OR =1 95 )和晚期血吸虫病 (巨脾型和腹水型 )家族史 (OR =2 11)。 [结论 ]血吸虫反复感染、感染间期越长、经常饮酒和有晚期血吸虫病家族史的血吸虫病患者肝组织发生纤维化的危险性也越大。

Objective] To explore the risk factors for schistosomal liver fibrosis.[Methods] 192 hepatitis negative patients with schistosomiasis were selected and divided into 3 groups according to the result of B ultrasound examination,that is,grade 2 and 3 fibrosis group(81 patients), grade 1 fibrosis group(61 patients) and control group (non fibrosis, 50 patiets).The univariate and multivariate ordinal regression model was made to analyse the possibly harmful factors influencing the liver damages of these patients. [Results] Four factors were found to be positively associated with schistosomal liver fibrosis.They were : number of treatments of schistosomiasis (OR=1 75),interval of schistosomal infection(OR=1 40),history of drinking wine(OR=1 95) and familial history of advanced schistosomiasis (OR=2 11). [Conclusion] Patients with repeated schistosome infection,long duration of schistosomal infection, long history of drinking and familial history of advanced schistosomiasis had higher risk for liver fibrosis than schistosomiasis patients without these factors.