高胰岛素血症对主要载脂蛋白及胆固醇的影响

Effects of hyperinsulinemia on cholesterol and major apolipoprotein

目的 探讨高胰岛素血症对血清胆固醇 (TC)、甘油三酯 (TG)、载脂蛋白 (APOA1)、载脂蛋白(APOB)的影响。方法 首次发作住院精神分裂症患者 ,以单纯使用抗精神病药物者为对照组 (2 0例 ) ,以抗精神病药物联合使用胰岛素治疗者为治疗组 (30例 ) ,治疗 2 0d后和治疗前的TC、TG、APOA1、APOB进行比较。结果 对照组治疗前后血清TC、TG、APOA1、APOB均无统计数差异 (P >0 .0 5 ) ,治疗组APOA1无统计学差异 (P >0 .0 5 ) ,试验组治疗后TC (P <0 .0 0 1)、TG (P <0 .0 5 )、APOB (P <0 .0 2 )均较治疗前数值升高。结论 高胰岛素血症可能通过影响人体脂质代谢 ,使TC、TG、APOB升高 ,从而引起高血压、冠心病。

Objective To research the effects of hyperinsulinemia on cholesterol(TC),triglyceride(TC),APO A? 1/ APO B. Method Fifty patients with schizophrenia were divided into control group(20 cases) treated by anti-psychosis medicine, treatment group(30 cases)treated by insulin and anti-psychosis medicine. The serum TC, TG, APO A? 1 and APO B of the in-patients with schizophrenia who first attack were compared , when they were treated for twenty days later and before treatment.Results The serum TC, TG, APO A? 1 and APO B in control group was not statistics difference(P>0.05) compared with that of before treatment . APO A? 1 of treatment groups was not statistics difference, but TC(P<0.001), TG(P<0.05)and APO B(P<0.02) possessed statisticdl difference.Conclusion The hyyperinsulinemia of patients may make TC, TG and APO B rise through affecting the metabolism of lipid. So it caused hypertension,coronary heart disease and atherosclerosis.