肾移植受者尿液可溶性白介素Ⅱ受体的动态监测及其意义

Dynamic observation and significance of soluble interleukin-2 receptor in the urine of renal transplant patients

目的 探讨可溶性白介素Ⅱ受体与肾移植术后患者排斥反应的关系。方法 对 42例肾移植患者分别于术前 1d及术后d3,d7,d14,d2 8采集血液和尿液 ,动态监测可溶性白介素 2受体 ,并与正常人比较。结果 尿毒症患者血清及尿液中的白介素Ⅱ受体浓度高于正常人 (P <0 .0 5 ) ;肾移植术后平稳患者 ,其可溶性白介素Ⅱ受体浓度接近正常人 ;术后发生急性排斥及感染时 ,可溶性白介素Ⅱ受体浓度显著高于平稳患者 (P <0 .0 5 )。结论 尿液可溶性白介素Ⅱ受体浓度监测可为移植肾急性排斥的早期诊断提供依据 ,对肾移植术后急性排斥反应。

Objective To study the relation ship between soluble interleukin-2 receptor and rejection of renal transplant patients,.Method The serum and urine soluble interleukin-2 receptor of renal transplant patients and the control group were dynamically monitored.T test was used to assess the statistical significance.Results Serum and urine interleukin-2 were higher in end-stage renal in disease patients than that in the control group,almost normal in successful renal transplant patients,and significantly higher in those who had acute rejection and infection.Conclusion Monitoring of the concentration of urine soluble interleukin-2 receptor are helpful in early diagnosis of acute rejection in renal transplant patients,and it's also a good reference in differentiating acute rejection,acute renel tabular necrosis and infection.