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噬血细胞性淋巴组织细胞增生症的诊断 被引量：6

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摘要 噬血细胞性淋巴组织细胞增生症（hemophagocytic lymphohistocytosis, HLH）又称噬血细胞综合征（hemophagocytic syndrome，HS），是由多种致病因素导致淋巴细胞、单核细胞和巨噬细胞系统异常激活、增殖。分泌大量炎性细胞因子引起的严重甚至致命的炎症状态。其本身并非独立的疾病，而是并发于各种基础疾病．表现为同一高炎症反应的表型．
作者 王昭
机构地区 首都医科大学附属北京友谊医院血液科
出处 《内科理论与实践》 2013年第3期157-162,共6页 Journal of Internal Medicine Concepts & Practice
关键词 噬血细胞性淋巴组织细胞增生症 炎症反应 诊断
分类号 R551.2 [医药卫生—血液循环系统疾病]
  • 相关文献

参考文献48

  • 1Verbsky JW, Grossman WJ. Hemophagocytic lymphohis- tiocytosis: diagnosis, pathophysiology, treatment, and fu- ture perspectives [J]. Ann Med, 2006, 38(1): 20-31.
  • 2Henter JI, Elinder G, Ost A. Diagnostic guidelines for hemophagocytic lymphohistiocytosis [J]. Semin Oncol, 1991, 18(1): 29-33.
  • 3Henter JI, Home A, Aric6 M, et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis [J]. Pediatr Blood Cancer, 2007, 48 (2): 124-131.
  • 4Filipovich AH. Hemophagocytic lymphohistiocytosis (HLH) and related disorders [J]. Hematology Am Soc Hematol Educ Program, 2009: 127-131.
  • 5Johnson TS, Villanueva J, Filipovich AH, et al. Contemporary diagnostic methods for hemophagocytic lymphohistiocytic disorders [J]. J Immunol Methods, 2011, 364(1-2): 1-13.
  • 6Harada H, Saijo K, Ishiwata I, et al. A GFP-transfected HFWT cell line, GHINK-1, as a novel target for non-RI activated natural killer cytotoxicity assay [J]. Hum Cell, 2004, 17(1): 43-48.
  • 7Chung HI, Park C J, Lim JH, et al. Establishment of a reference interval for natural killer cell activity through flow cytometry and its clinical application in the diagnosis of hemophagocytic lymphohistiocytosis [J]. Int J Lab Hematol, 2010, 32(2): 239-247.
  • 8吴林,王昭,陈皙,王旖旎,王晶石.流式细胞术检测NK细胞活性在获得性噬血细胞性淋巴组织细胞增多症诊断中的应用[J].中国实验血液学杂志,2009,17(6):1497-1501. 被引量：4
  • 9Marcenaro S, Gallo F, Martini S, et al. Analysis of naturalkiller-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Muncl3-4 defect and discriminates between genetic subtypes of the disease [J]. Blood, 2006, 108(7): 2316-2323.
  • 10Marsh RA, Bleesing J J, Filipovich AH. Using flow cytometry to screen patients for X-linked lympho- proliferative disease due to SAP deficiency and XIAP deficiency [J]. J Immunol Methods, 2010, 362(1-2): 1-9.

二级参考文献16

  • 1Zur Stadt U,Beutel K,Kolberg S. Mutation spectrum in children with primary hemophagocytic lymphohistioeytosis:molecular and functional analyses of PRF-1,UNC13D,STX11,and RAB27A[J].Human Mutation,2006.62-68.
  • 2Henter JI,Home AC,Arico M. HLH-2004:Diagnostic and therapeutic guidelines for hemophagocytic lymphohistioeytosis[J].Pe-diatr Blood Cancer,2007.124-131.
  • 3Janka GE. Familial and acquired hemophagocytic lymphohistioeytosis[J].European Journal of Pediatrics,2007.95-109.
  • 4Clementi R,Emmi L,Maccario R. Adult onset and atypical presentation of hemophagocytic lymphohistioeytosis in siblings carrying PRF1 mutations[J].Blood,2002.2266-2267.
  • 5Mancebo E,Allende LM,Guzman M. Familial hemophagocytic lymphohistioeytosis in an adult patient homozygous for A91V in the perform gene,with tuberculosis infection[J].Haematologica,2006.1257-1260.
  • 6Nagafuji K,Nonami A,Kumano T. Perform gene mutations in adult-onset hemophagocytic lymphohistioeytosis[J].Haematologica,2007.978-981.
  • 7Janka GE,Schneider EM. Modern management of children with haemophagocytic lymphohistioeytosis[J].British Journal of Haematology,2004.4-14.
  • 8Farquhar JW,Claireaux AE. Familial haemophagocytic reticulo-sis[J].Archives of Disease in Childhood,1952.519-525.doi:10.1136/adc.27.136.519.
  • 9Cetica V,Pende D,Griffiths GM. Molecular basis of familial hemophagocytic lymphohistioeytosis[J].Haematologica,2010.538-541.
  • 10Okur H,Balta G,Akarsu N. Clinical and molecular aspects of Turkish familial hemophagocytic lymphohistioeytosis patients with perform mutations[J].Leukemia Research,2008.972-975.

共引文献17

同被引文献64

  • 1王艳荣,邹典定,周东风.儿童嗜血细胞综合征10例临床分析[J].医学新知,2006,16(1):51-52. 被引量：6
  • 2Zur S U, Beutel K, Kolberg S, et al.Mutaion spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses ofPRF1, UNC13D, STX11 and RAB27A[J].Hum Murat, 2006, 27 ( 1 ) : 62-68.
  • 3Stepp S E, Dufourcq-Lagelouse R, Le D F, et al.Perforin gene defects in familial hemophagocytic lymphohistiocytosis[J].Science, 1999, 286 (5446) : 1957-1959.
  • 4Schmid J P, Cote M, Menager M M, et al.Inherited defects in lymphocyte cytotoxic activity[J].Immunol Rev, 2010, 235 (6) : 10- 23.
  • 5Ueda I, Ishii E, Morimoto A, et al.Correlation between phenotypic heterogeneity and gene mutational characteristics in familial hemophagocytic lymphohistiocytosis ( FHL ) [J].Pediatr Blood Cancer, 2006, 46 ( 4 ) : 482-488.
  • 6Voskoboinik I, Dunstone M A, Baran K, et al.Perforin: structure, function, and role in human immunopathology[J].Immunol Rev, 2010, 235 (16) : 35-54.
  • 7Feldmann J, Callebaut I, Raposo G, et al.Muncl3-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis ( FHL3 ) [J].Cell, 2003,115 ( 4 ): 461-473.
  • 8Zur S U, Schmidt S, Kasper B , et al.Linkage of familial hemophagocytic lymphohistiocytosis ( FHL ) type-4 to chromosome 6q24 and identification of mutations in syntaxin 1 l[J].Hum Mol Genet, 2005, 14 ( 6 ) : 827-834.
  • 9Zur S U, Rohr J, Seifert W, et al.Familial hemophagocytic lymphohistiocytosis type 5 ( FHL-5 ) is caused by mutation in Muncl8-2 and impaired binding to syntaxin 11[J].Am J Hum Genet, 2009, 85 ( 4 ) : 482-492.
  • 10Munson M, Hughson F M.Conformational regulation of SNARE assembly and disassembly in vivo[J].J Biol Chem, 2002, 277 ( 11 ) : 9375-9381.

引证文献6

二级引证文献11

内科理论与实践
2013年 第3期

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