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“鸡尾酒”式免疫干预法防治1型糖尿病的最新研究进展

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摘要 1型糖尿病（T1DM）是一种自身免疫性疾病，以遗传为基础．在某些环境因素作用下．诱发机体免疫系统功能障碍导致胰岛β细胞自身免疫性损伤，使其丧失合成和分泌胰岛素能力，引起糖代谢调节絮乱的自身免疫性疾病；
作者 王柏凯 张娟娟 顾卫琼
机构地区 上海交通大学医学院附属瑞金医院内分泌科 上海市内分泌代谢病研究所
出处 《内科理论与实践》 2013年第3期221-224,共4页 Journal of Internal Medicine Concepts & Practice
关键词 1型糖尿病 免疫干预 联合疗法 造血干细胞 移植
分类号 R587.1 [医药卫生—内分泌]
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参考文献24

  • 1Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes [J]. Nature, 2010, 464(7293): 1293-1300.
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  • 10Bresson D, Togher L, Rodrigo E, et al. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs [J]. J Clin Invest, 2006, 116(5): 1371-1381.

二级参考文献20

  • 1Bottini N.Role of PTPN22 in type 1 diabetes and other autoimmune diseases,Seminars in Immunology.2006,18:207-213.
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  • 7Tyndall A,Fassas A,Passweg J,et al.Autologous haematopoietic stem cell transplants for autoimmune disease-feasibility and transplantrelated mortality.Autoimmune disease and lymphoma working parties of theEuropean group for blood and marrow transplantation,the european league against rheumatism and the international stem cell project for autoimmune disease.Bone Marrow Transplant,1999,24:729-734.
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内科理论与实践
2013年 第3期

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