镁离子与冠心病关系的研究进展

Research progress of magnesium ion and coronary heart disease

镁离子（Mg^2＋）为细胞内含量最多的二价阳离子。人体内Mg^2＋的主要来源为饮食摄人，主要经回肠吸收，肾脏为其重要排泄器官。机体中Mg^2＋浓度受多种因素调节，如甲状旁腺激素、降钙素、去甲。肾上腺素和肾上腺素等多种激素都影响镁的转运。近年来研究发现细胞膜上瞬时受体电位阳离子通道M7（transient receptor potential cation channel subfami-ly Mmember7，TRPM7）和M6（TRPM6）对机体Mg^2＋稳态的调控起重要作用，其介导的Mg^2＋电流亦有重要生理作用。

Magnesium ion （Mg^2＋ ） is the most abundant divalent cation in the human cells, which plays an important role in cellular activities. In the cardiovascular system, Mg^2＋ is one of the most important cationic ions studied following calcium and potassium. Mg^2＋ -related diseases include atherosclerosis, hypertension, cardiac hypertrophy, and so on. Here we review the relationship between Mg^2＋ and the coronary atherosclerotic heart disease.