摘要
骨桥蛋白(osteopontin,OPN)是一种分泌性磷酸化糖蛋白,首先发现于人体正常组织中,是重要的黏附因子之一.随着研究的深入,在许多肿瘤侵袭、进展及转移过程中亦可见OPN表达升高.OPN在肝癌(hepatocellular carcinoma,HCC)的转移复发过程中占有重要地位,是一种肿瘤标志物,也可能成为一种新的抗癌治疗靶点.本文对OPN的分子、生理特性,OPN在HCC转移复发中的相关机制,诊断预测及治疗进行综述.
Osteopontin （OPN）, first found in normal human tissue, is a secreted phosphorylated glycoprotein and one of the most important adhesion factors. Increased expression of OPN has been found in many types of tumors. OPN plays a very important role in the metastasis and recurrence of hepatocellular carcinoma （HCC）. As a tumor marker, OPN may also become a new therapeutic target for cancer. This review aims to elucidate the structure and function of OPN, its role in HCC recurrence and metastasis, and the significance of OPN in HCC diagnosis and treatment. 2013 Baishideng. All rights reserved
出处
《世界华人消化杂志》
CAS
北大核心
2013年第16期1498-1504,共7页
World Chinese Journal of Digestology
基金
江苏高校优势学科建设工程基金资助项目
No.YS2012ZYX109
江苏省科技厅基础研究计划基金资助项目
No.BK2010563~~
关键词
骨桥蛋白
肝癌
转移
复发
Osteopontin
Hepatocellular carcinoma
Metastasis
Recurrence
