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Adult neurogenesis in the mammalian brain 被引量：1

Adult neurogenesis in the mammalian brain
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摘要 New neurons are generated throughout life in distinct areas of the mammalian brain. This process, called adult neurogenesis, has challenged previously held concepts about adult brain plasticity and opened novel therapeutic avenues to treat certain neuro-psychiatric diseases. Here, we review the current knowledge regarding the fate and potency of neural stem cells （NSCs）, as well as the mechanisms underlying neuronal differentiation and subsequent integration. Furthermore, we discuss the functional significance of adult neurogenesis in health and disease, and offer brief insight into the future directions of the adult neurogenesis field. New neurons are generated throughout life in distinct areas of the mammalian brain. This process, called adult neurogenesis, has challenged previously held concepts about adult brain plasticity and opened novel therapeutic avenues to treat certain neuro-psychiatric diseases. Here, we review the current knowledge regarding the fate and potency of neural stem cells （NSCs）, as well as the mechanisms underlying neuronal differentiation and subsequent integration. Furthermore, we discuss the functional significance of adult neurogenesis in health and disease, and offer brief insight into the future directions of the adult neurogenesis field.
作者 Simon M.G. BRAUN Sebastian JESSBERGER
机构地区 Brain Research Institute Neuroscience Center Zurich
出处 《Frontiers in Biology》 CAS CSCD 2013年第3期295-304,共10页 生物学前沿（英文版）
关键词 adult neurogenesis HIPPOCAMPUS stem cell MEMORY neuropsychiatric disease adult neurogenesis hippocampus stem cell memory neuropsychiatric disease
分类号 Q421 [生物学—神经生物学] TP18 [自动化与计算机技术—控制理论与控制工程]
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Frontiers in Biology
2013年 第3期

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