摘要
采用界面聚合法,以聚乙烯醇为保护胶体,曲拉通X-100为乳化剂,超支化聚L-赖氨酸和对苯二甲酰氯为壁材,咖啡因为模型药物,制备了pH响应型药物微胶囊。利用正交实验研究了高速剪切速度,剪切时间,保护胶体用量,乳化剂用量对微胶囊包封率的影响。表征了微胶囊的结构、形貌、粒径大小及其分布,研究了微胶囊在不同pH的缓冲溶液中的药物释放行为。结果表明:所制备微胶囊的壁材和芯材分别由超支化聚L-赖氨酸与对苯二甲酰氯反应产物和咖啡因组成;所得微胶囊呈规则的球形,具有较光滑的表面;微胶囊的粒径分布集中,并呈正态分布。微胶囊的药物释放行为对不同pH的缓冲溶液表现出明显的依赖性。
The pH-sensitive microcapsules were prepared by interracial polymerization, in which caffeine was used as a model drug and hyperbranched poly L-lysine(HBPL) and terephthaloyl chloride as wall-forming materials. Using statistical analysis of orthogonal experiment, the effects of the emulsifying rate, emulsifying time, protective colloid content and content of e- mulsifier on the encapsulation efficiency of the microcapsules were discussed. The structure and particle size distribution and surface of microcapsules were characterized. The release be- haviours of caffeine in different phosphate buffered saline(PBS) pH were investigated system- atically. As a result, caffeine was successfully encapsulated in the wall-forming materials. The resultant microcapsules had the narrow particle size distribution and smooth surface. These drug-loaded microcapsules have shown sensitivity to pH value.
出处
《河北农业大学学报》
CAS
CSCD
北大核心
2013年第3期102-106,共5页
Journal of Hebei Agricultural University
基金
河北大学医学学科专项资金建设项目(2012A3002)
关键词
pH响应型微胶囊
界面聚合
超支化聚L-赖氨酸
药物释放
正交实验
pH-sensitive microcapsules
interfacial polymerization
hyperbranched poly L-lysine
drug release properties
statistical analysis of orthogonal experiment