FAK和uPA在唾液腺腺样囊性癌中的表达

Expression of Focal Adhesion Kinase and Urokinase-type Plasminogen Activator in Salivary Adenoid Cystic Carcinoma

目的探讨粘着斑激酶(FAK)、尿激酶型纤溶酶原激活物(uPA)在腺样囊性癌(ACC)中的表达和相关性,及两者与腺样囊性癌的临床病理类型的关系。方法应用免疫组织化学方法检测40例唾液腺腺样囊性癌、30例多形性腺瘤和30例正常唾液腺组织中FAK、uPA的表达。结果 FAK、uPA的阳性表达率计数在正常唾液腺组织、多形性腺瘤、ACC中依次增加,组间差异具有统计学意义(P<0.05);转移组高于非转移组,神经侵犯组高于非侵犯组(P<0.05)。结论 FAK、uPA在ACC中的表达有相关性,并与ACC的临床类型密切相关,可以作为判断ACC侵袭、转移及预后的重要指标。

OBJECTIVE To investigate the focal adhesion kinase （FAK） and urokinase-type plasminogen activator（uPA） expression in adenoid cystic carcinoma （ACC） and the correlation between them, and relationship between FAK, uPA and clinical pathological type of adenoid cystic carcinoma. METHODS Immunohistochemistry method was used. Forty cases of salivary adenoid cystic carcinoma, 30 cases of pleomorphic adenoma and 30 cases of normal salivary gland tissue of FAK and uPA expression were detected. RESULTS FAK and uPA, the positive expression rate in normal salivary gland tissue, pleomorphic adenoma, ACC, in turn increased, the difference between the groups was statistically significant（P〈0.05）; transfer group were higher than that of the non-metastatic group, nerve invasion group were higher than that of non-infringement group（P〈0.05）. CONCLUSION Expression of FAK and uPA in the ACC is closely correlated, they are related with the ACC clinical types, which can be used as an important indicator to judge the ACC invasion, metastasis and prognosis.