膏摩法结合超声药物透入治疗颈源性肩背痛的疗效观察

Clinical Observation on the Curative Effect of the Cervicogenic Shoulder and Backache by Cream Friction Law Combined with Ultrasonic Drug Penetration

目的观察膏摩法结合超声药物透入治疗颈源性肩背痛的疗效及相关效应因子的调节变化。方法将符合要求的96例颈源性肩背痛患者随机分为2组,治疗组48例,对照组48例。治疗组以膏摩法结合超声药物透入疗法,对照组采用常规手法结合口服塞来昔布胶囊治疗。分别观察2组治疗前后的疗效及相关炎性因子白细胞介素-1β受体拮抗剂、白细胞介素-6及肿瘤坏死因子的浓度变化,并参照标准进行临床疗效的评定。结果治疗后2组的血清白细胞介素-1β受体拮抗剂浓度均增加,治疗组增加程度大于对照组;2组血清白细胞介素-6浓度均有降低,治疗组降低程度大于对照组;2组血清肿瘤坏死因子浓度均有降低,治疗组降低程度大于对照组。治疗组总有效率91.7%,对照组总有效率75.0%,治疗组疗效优于对照组(P<0.05)。结论膏摩法结合超声药物透入治疗颈源性肩背痛的疗效优于常规手法及服药,能调节血清中白细胞介素-1、白细胞介素-6和肿瘤坏死因子等的浓度,是治疗颈源性肩背痛较为有效的方法。

OBJECTIVE To observe the curative effect of cream friction combined with ultrasonic drug penetration for treating cervicogenic shoulder pain and to observe the related effective factors regulation change. METHODS Randomly divide 96 patients suffering from cervicogenic shoulder and back pain into two groups, in which 48 patients were in treatment group, the other 48 patients in control group. Adopt cream friction combined with ultrasonic drug penetration for treatment group, and regular manipulation combined with oral administration of celecoxib capsules for control group. Observe effect and concentration change of these related inflammatory factors such as IL-1β receptor antagonist, IL-6 and TNF before and after treatment respectively. And estimate clinical effect based on reference standard. RESULTS After treatment, the concentration of IL-1β receptor antagonist in both groups increased, while in treatment group, it was more obvious; and the concentration of IL-6 in blood plasm in both groups decreased, while in treatment group, it was more obvious. TNF concentration in blood plasm in both groups decreased, while in treatment group, it was more obvious. In terms of clinical effect rate, the treatment group was 91.7%, control group was 75%. Therefore, treatment group was better than control group（P〈0.05）. CONCLUSION Cream friction combined with ultrasonic drug penetration is effective method to treat cervicogenic shoulder and back pain, which is more effective than regular manipulation combined with oral drugs. The former method can regulate IL-1, IL-6 and TNF concentration in blood plasm.