P300/环腺苷酸效应元件结合蛋白及其生物学功能

P300/cyclic adenosine monophosphate response element binding protein and its biological functions

转录共激活因子P300/环腺苷酸效应元件结合蛋白结合蛋白(CBP)因分别与腺病毒癌蛋白E1A及环腺苷酸效应元件结合蛋白相结合而得名。P300/CBP可影响细胞增殖、分化和程序性死亡等。本文就P300/CBP的结构、功能、作用机制以及对转录因子和细胞周期因子等的调控作用等研究进展作一综述。

P300 and cyclic adenosine monophosphate response element binding protein（CBP） were originally identified as transcriptional co-activator proteins that bind to the adenoviral E1A and the cyclic adenosine monophos- phate-response element binding protein, respectively. They play a central role in multiple physiological events, for example, cell proliferation, differentiation and apoptosis. The transcription regulating properties of P300/CBP appear to be exerted through multiple mechanisms. This article intended to give a review on the structures, functions and mechanisms of P3OO/CBP, and its effects on transcription factors and cell cycle-associated factors.