甲状腺占位性病变剪切波速度与组织纤维化评分之间的相关性研究

Correlation research of shear wave velocity and tissue fibrosis score of thyroid space-occupying lesions

【摘要】目的探讨甲状腺占位性病变剪切波速度与组织纤维化评分之间的相关性。方法应用声触诊组织量化技术检测甲状腺占位性病变55个，对病灶不同部位实性部分的剪切波速度进行多次测量，取得15个测量结果。去掉最大值和最小值，用其余的13个数据算出剪切波速度最大值（Vmax）、最小值（Vmin）、平均值（Vm）。在光学显微镜下观察病理切片上病灶的纤维化程度并进行评分，算出最大值（Fmax）、最小值（Fmin）和平均值（Fro）。然后，统计分析良性病灶与恶性病灶的Fmax、Fmin、Fm之间有无差异；统计分析Fmax与Vmax、Fmin与Vmin、Fm与Vm之间的直线相关关系。结果55个病灶中，良性3（）个，恶性25个。良性病灶Fmax、Fmin、Fm分别为1．38±1．44、0．68±0．25、0．91±0．73；恶性病灶分别为5．00±1．91、3．52±1．82、4．08±1．75。上述变量良性组与恶性组之间差异有统计学意义（t检验，P〈0．01）。Fmax与Vmax、Fmin与Vmin、Fm与Vm之间均有直线相关关系，Pearson相关系数分别为0．504、0．284、0．453。结论甲状腺占位性病变剪切波速度与组织纤维化程度之间有一定相关性。纤维化程度越重、剪切波速度越快。

Objective To investigate the correlation between shear wave velocity and tissue fibrosis score in thyroid space-occupying lesions. Methods The shear wave velocity of 55 thyroid space-occupying lesions was examined by virtual touch tissue quantification. The shear wave velocity of different solid parts of the lesions was detected for several times and 15 data were genarated. Then maximum and minimum value were removed. The maximum （Vmax）, minimum （Vmin）, mean （Vm） of shear wave velocity were calculated with the rest of 13 data. Meantime the fibrosis degree of these pathological lesions were scored by using optical micorscope. The maximum （Fmax）, minimum （Fmin） and mean （Fro） fibrosis degree were calculated with these scores. Then the difference between Fmax, Fmin and Fm value of benign lesions and malignant lesions was analyzed. The linear correlation between Fmax and Vmax, Fmin and Vmin, Fm and Vm was also analysed. Results In the 55 lesions,30 lesions were benign and the rest was malignant. The Fmax, Fmin, Fm o{ benign lesions were 1.38 ± 1.44, 0.68 ± 0.25, 0.91 ± 0.73 respectively; the corresponding value of malignant lesions were 5.00 ± 1.91,3.52 ± 1.82,4.08 ± 1.75 respectively. There was significant difference between the benign group and malignant group （ t test, P 〈0.01）. There were linear correlation between Fmax and Vmax,Fmin and Vmin,Fm and Vm and the Pearson correlation coefficients were 0. 504,0. 284,0. 453 respectively. Conclusions The shear wave velocity and fibrosis degree of thyroid lesions has linear relationship. The heavier the degree of fibrosis is, the faster the shear wave velocity would be.