实时剪切波弹性成像检测正常成人肝弹性模量正常值的研究

Quantitative study of normal value in health liver by real-time shear wave elastography

【摘要】目的探讨实时剪切波弹性成像（real—time shear wave eiasmgraphy，SWE）技术检测肝硬度的可行性，建立成年人正常肝剪切波弹性模量参考值范围。方法应用SWE技术，对335例健康体检者进行肝弹性模量值检测，获得正常值范围，分析性别及年龄对肝弹性模量的影响，其中30例受检者经两位医生分别检测。结果335例受检者中有329例成功，成功率为98．2％。正常肝弹性模量均值为（5．023±0．966）kPa，95％可信区间为4．918—5．128kPa，不同年龄及性别组间测值比较差异无统计学意义（P=0．218、P=0．271），不同操作者对同一组受检者检测的肝弹性模量均值差异无统计学意义（P：0．498），组间相关系数ICC为0．925。结论SWE技术评估正常成人肝硬度的重复性及稳定性好，成年人正常肝实时剪切波弹性模量均值为（5．023±0．966）kPa；性别及年龄对肝弹性模量值检测无影响。

Objective To explore the feasibility of detecting liver stiffness by real time shear wave elastography （SWE） and establish a reference range of shear modulus in healthy liver of adults. Methods 335 adults underwent SWE detection to obtain the shear modulus of livers. The effects of different gender and age on the shear modulus in normal adult were analyzed. Thirty subjects were performed by two operators respectively to evaluate interobserver agreement. Results 329 health volunteers were detected successfully. The success rate was 98.2~. The mean value of SWE measurements in normal individuals was （5. 023 ＋ 0. 966）kPa. The liver shear modulus of healthy adults had a 95 G confidence interval from 4. 918 - 5. 128 kPa. There were no significant differences between the mean SWE values in men vs women （ P = 0. 218） ,also among different age groups （ P = 0. 271）. No statistically significant was observed between the mean SWE values obtained by two different operators （ P = 0. 498）, interobserver ICC value was 0925. Conclusions SWE is a repeatability and stabiiity method to access liver stiffness on healthy subjects. In our study the mean liver stiffness value obtained by SWE in healthy subjects was 5. 023 kPa. The mean liver stiffness value obtained by SWE did not influenced by sex and age.