介入硬化剂聚桂醇治疗子宫内膜异位囊肿的实验研究

Experimental study on lauromacrogol in sclerotherapy of endometrial cyst models

【摘要】目的通过动物实验探讨聚桂醇在硬化治疗子宫内膜异位囊肿的价值。方法45只SD大鼠行子宫内膜异位囊肿造模后随机分为聚桂醇治疗组、无水乙醇治疗组和生理盐水对照组，分别向各组子宫内膜异位囊肿内注入相应药物，1周后病理观察囊肿模型异位内膜的病理形态学变化及VEGF的表达情况。结果聚桂醇组和无水乙醇组均可见异位囊肿内膜腺体破坏，其中囊肿治愈率聚桂醇组为87．5％，无水乙醇组为85．0％，两组间治愈率差异无统计学意义（P=1．000），生理盐水对照组异位囊肿内膜腺体未见明显破坏；聚桂醇组和无水乙醇组VEGF的表达均低于生理盐水组（P分别为0．003、0．006），而聚桂醇组VEGF表达与无水乙醇组比较，差异无统计学意义（P=0．926）。结论聚桂醇能致异位子宫内膜失活，对子宫内膜异位囊肿模型的硬化治疗能达到同无水乙醇相同的疗效。

Objective To investigate the value of the lauromacrogol in sclerosis therapy of endometrial cyst models of SD rat. Methods 45 SD rats were randomly divided into lauromacrogol treatment group, dehydrated alcohol treatment group and physiological saline blank group after being built cysts models. Then corresponding medicine was injected into the cysts,and the changes of pathomorphology and VEGF expression of ectopia endomembrane were observed a week later. Results Microscope observation indicated that endometrial cyst glandular epithelium and gland were inactived by both lauromacrogol and dehydrated alcohol. The effective rate of lauromacrogoI group was 87.5%, and that of dehydrated alcohol group was 85.0%. There was no significant difference between these two methods （ P = 1. 000）. The ectopia endomembrane glandular organs of physiological saline group were not destructed obviously. Besides, VEGF expression of lauromacrogol and dehydrated alcohol group were lower than physiological saline group （ P = 0. 003 and 0. 006）. There was no significant difference between VEGF expression of lauromacrogol and dehydrated alcohol group （ P = 0. 926）. Conclusions Compared with dehydrated alcohol, lauromacrogol had the same therapeutic effect on sclerosis therapy of endometrial cyst models.