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丙型肝炎病毒体外细胞培养的新进展 被引量：2

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摘要 丙型肝炎病毒（hepatitisCvirus，HCV）发现于1989年，目前全球约1．7亿人感染，占世界人口总数的3％，大多数的急性感染者会发展为慢性肝炎并与肝硬化和肝癌的发生密切相关。自HCV发现之后近20年的时间里，由于缺乏理想可靠的细胞及动物培养模型，人们在HCV生活周期、致病与免疫保护、
作者 张玲 谭文杰
机构地区 中国疾病预防控制中心病毒病预防控制所
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2013年第6期465-469,共5页 Chinese Journal of Microbiology and Immunology
关键词 体外细胞培养 丙型肝炎病毒 世界人口 慢性肝炎 培养模型 生活周期 免疫保护 感染者
分类号 R3 [医药卫生—基础医学]
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参考文献39

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同被引文献22

  • 1Igor Bakulin,Victor Pasechnikov,Anna Varlamicheva,Irina Sannikova.NS3 protease inhibitors for treatment of chronic hepatitis C: Efficacy and safety[J].World Journal of Hepatology,2014,6(5):326-339. 被引量：2
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  • 3Wakita T,Pietschmann T,Kato T,Miyamoto M,Zhao Z,Murthy K,Habermann A,Krusslich HG,Mizokami M,Bartenschlager R,Liang T.Production of infectious hepatitis C virus in tissue culture from a cloned viral genome[J].Nat Med,2005,11(7):791-796.
  • 4Lindenbach B D,Evans MJ,Rice C M,Wlk B,Tellinghuisen T L,Liu C C,Maruyama T,Hynes R O,urton D R,McKeating J A,Rice C M.Complete replication of hepatitis C virus in cell culture[J].Science,2005,309(5734):623-626.
  • 5Pietschmann T,Kaul A,Koutsoudakis G,Shavinskaya A,Kallis S,Steinmann E,Abid K,Negro F,Dreux M,Cosset F L,Bartenschlager R.Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras[J].Proc Natl Acad Sci USA,2006,103(19):7408-7413.
  • 6Gottwein J M,Scheel T K,Hoegh A M,Lademann J B,Eugen-Olsen J,Lisby G,Bukh J.Robust hepatitis C genotype 3acell culture releasing adapted intergenotypic 3a/2a(S52/JFH1)viruses[J].Gastroenterology,2007,133(5):1614-1626.
  • 7Scheel T K,Gottwein J M,Jensen T B,Prentoe J C,Hoegh A M,Alter H J,Eugen-Olsen J,Bukh J.Development of JFH1-based cell culture systems for hepatitis C virus genotype 4aand evidence for cross-genotype neutralization[J].Proc Natl Acad Sci USA,2008,105(3):997-1002.
  • 8Li Y P,Ramirez S,Jensen S B,Purcell R H,Gottwein J M,Bukh J.Highly efficient full-length hepatitis C virus genotype 1(strain TN)infectious culture system[J].Proc Natl Acad Sci USA,2012,109:19757-62.
  • 9Gottwein J M,Scheel T K,Jensen T B,Lademann J B,Prentoe J C,Knudsen M L,Hoegh A M,Bukh J.Development and characterization of hepatitis C virus genotype 1-7cell culture systems:role of CD81and scavenger receptor class B type I and effect of antiviral drugs[J].Hepatology,2009,49(2):364-377.
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中华微生物学和免疫学杂志
2013年 第6期

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