中药桔梗对替米考星在肺脏中药物浓度的影响

Effect of Platycodon grandiflorum on Concentration of Tilmicosin in Lung Tissues

为探讨桔梗"载药上行"的引经作用,给鸡添加桔梗和替米考星,以探讨桔梗对替米考星在肺脏中药物浓度的影响。试验组饮水添加不同浓度桔梗煎液,4周后对照组和试验组统一注射替米考星注射液,提取肺脏,用高效液相色谱法(HPLC)检测肺组织中替米考星药物浓度。结果显示,桔梗可提高替米考星在鸡肺组织中的药物浓度。表明中药桔梗的"载药上行"功效是确实的。

Platycodon grandiflorum has “direct medicines ascending” action documented in the ancient Chinese medicinal book. For studying medicinal direct theory of Platycodon grandiflo- rum, we have added Platycodon grandiflorum on chicken＇s drinking water, and then injected tilmicosin in order to investigate the effect of Platycodon grandiflorum on concentration of tilmi- cosin residues in lung tissues. We have offered drinking water containing different concentrations of Platycodon grandiflorum to experimental chickens for 4 weeks, and then the control group and experimental group were injected tilmicosin. Tilmicosin was extracted from lung tissues and detected by using high performance liquid chromatography （HPLC）. The results showed that Platycodon grandiflorurn can improve tilmicosin concentration in chicken lung tissue. These re- sults conformed that Platycodon grandiflorum does have “direct medicines ascending” property.