人工流产术前、术后应用缩宫素鼻喷雾剂对减少出血的临床研究

Clinical Effect of Oxytocin Nasal Spray on Post-abortional Bleeding

目的:评价人工流产术前、术后应用缩宫素鼻喷雾剂对减少术中和术后出血的临床效果。方法:试验组200例在手术开始前给予缩宫素鼻喷雾剂,左、右侧鼻腔各1喷(共8 U),术后每日4次直至阴道出血结束。对照组200例不使用缩宫素鼻喷雾剂。观察患者术中出血量、手术时间和术后阴道出血天数。结果:术中出血量试验组为5.6±2.2 ml,对照组为10.9±8.1 ml(t=8.87,P<0.01);手术时间试验组为7.2±2.0 min,对照组为7.6±1.8 min(t=1.264,P>0.05);术后平均阴道出血天数试验组为5.0±1.9 d,对照组为6.2±1.7 d(t=6.474,P<0.01)。结论:人工流产术前、后给予缩宫素鼻喷雾剂能显著减少手术中和手术后出血。

Objective： To evaluate the clinical effect of oxytocin nasal spray administered before surgical termination of first-trimester pregnancy on postoperative bleeding. Methods： A randomized controlled trial was conducted. Four hundred women undergoing surgical termination of first-trimester pregnancy were recruited and randomized to 2 groups： oxytocin group （test group, n=200） which was sprayed oxytocin nasal spray 8 U before procedure and control group which received no oxtocic agent. The amount of blood loss, operative time and the days of vaginal bleeding were observed. Results： The amount of blood loss was 5.6 ± 2.2 ml in oxytocin group vs 10.9±8.1 ml in the control （t=8.87, P〈0.01）. There was no significant difference in the duration of the procedure between oxytocin group （7.3 _ 2.0 min） and the control （7.6 _ 1.8 min） （t=1.264, P〉0.05）. The days of vaginal bleeding were 5.0 ± 1.9 d in oxytocin group and 6.2 ± 1.7 d in the control （t=6.474, P〈 0.01）. Conclusion： Oxytocin nasal spray is a new dosage form for nasal administration. Spraying 8 U oxytocin nasal before operation can effectively reduce the blood loss and postoperative bleeding.