剖宫产后早孕药物流产加服米非司酮的临床观察

Clinical Observation on Medical Termination of Early Pregnancy after Cesarean Section by Plus Oral Mifepristone

目的:探讨剖宫产后早孕药物流产加服米非司酮是否能提高完全流产率。方法:剖宫产后再次妊娠(停经≤49 d)行药物流产的孕妇240例,随机分为研究组和对照组。对照组120例,米非司酮75 mg/d(早50 mg,晚25 mg)连用2 d,第3日口服米索前列醇600μg;研究组120例,在对照组的基础上,服用米索前列醇后加服米非司酮25 mg,bid×3 d。结果:研究组和对照组的完全流产率分别为92.50%和73.33%,差异有统计学意义(P<0.01),阴道流血时间分别为11.0±4.0 d和14.7±5.4 d,差异有统计学意义(P<0.01)。结论:剖宫产后早孕药物流产加服米非司酮25 mg,bid×3 d,可提高完全流产率,缩短阴道流血时间。

Objective： To investigate whether the medical termination plus oral mifepristone can increase the complete abortion rate of early pregnancy after cesarean section. Methods： A total of 240 cases of early pregnancy （amenorrhea ≤ 49 d） after cesarean section were randomly divided into study group and control group, 120 cases of the control received the oral dose of 75 mg mifepristone for 2 d （50 mg in the morning, 25 mg in the evening）, followed by misoprostol of 600 μg orally in the morning of the 3rd day. Another 120 cases of the study group took the mifepristone and misoprostol just like the control, after that, 150 mg mifepfistone was given in separate doses （25 mg, bid × 3 d）. Results： The complete abortion rates in the study group and the control were 92.50% and 73.33% （P〈0.01）, respectively. The duration of bleeding days in the study group and the control were 11.0 ± 4.0 d and 14.7 ± 5.4 d （P〈0.01）, respectively. Conclusion： Medical termination of early pregnancy after cesarean section by plus oral mifepristone 25 mg, bid × 3 d can increase the complete abortion rate, shorten the duration of bleeding days, suggesting that it＇s an effective and safe method.