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Ⅱ型跨膜丝氨酸蛋白酶的最新研究进展 被引量：4

Progress on type Ⅱ transmembrane serine protease
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摘要 Ⅱ型跨膜丝氨酸蛋白酶(TTSPs)是一类通过氨基末端跨膜区域锚定在细胞膜上的丝氨酸蛋白酶。激活后的TTSPs通过其特异性底物参与多种生理和病理过程,功能异常可导致肿瘤、耳聋、缺铁性贫血、心血管疾病等。 The type are anchored on the cleave their specific of these TrSPs may Ⅱ transmembrane serine protease （1TSP） family includes a group of trypsin-like enzymes that cell surface via an integral transmembrane domain near the N-terminus. The activated TFSPs substrates to participate in a variety of physiological and pathological processes. Dysregulation lead to serious diseases such as cancer, hearing loss, anemia and cardiovascular disease.
作者 高利娟 董宁征 吴庆宇
机构地区 苏州大学唐仲英血液学研究中心
出处 《基础医学与临床》 CSCD 北大核心 2013年第7期915-918,共4页 Basic and Clinical Medicine
基金 国家自然科学基金(31070716 81170247)
关键词 Ⅱ型跨膜丝氨酸蛋白酶 癌症 耳聋 缺铁性贫血 心血管疾病 33SPs cancer heanng loss anemia cardiovascular disease
分类号 R341 [医药卫生—基础医学]
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参考文献15

  • 1Antalis TM, Bugge TH, Wu Q. Membrane-anchored serine proteases in health and disease [ J]. Prog Mol Biol Transl Sci, 2011,99: 1-50.
  • 2Qi x, Jiang J, Zhu M, et al. Human corin isoforlns with different cytoplasmic tails that alter ce|| surface targeting [J]. J Biol Chem, 2011, 286:20963-20969.
  • 3Uh|and K. Matriptase and its putative role in cancer [ J]. Cell Mol Life Sci, 2006, 63:2968-2978.
  • 4Tripathi M, Potdar AA, Yamashita H, et al. Laminin-332 cleavage by matriptase alters motility parameters of prostate caneer cells [J]. Prostate, 2011,71: 184- 196.
  • 5Bocheva G, Rattenholl A, Kempkes C, et al. Role of malriptase and proteinase-activated receptor-2 in nonmela- noma skin cancer [ J]. J Invest Dermatol, 2009, 129: 1816 - 1823.
  • 6Moran P, Li W, Fan B, et al. Pro-urokinase-type p|as- minogen activator is a substrate for hepsin [ J ]. J Biol Chem, 2006, 281:30439-30446.
  • 7Tripathi M, Nandana S, Yamashita H, et al. Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression [ J ]. J Biol Chem, 2008, 283: 30576 - 30584.
  • 8Ganesan R, Kolumam GA, Lin SJ, et al. Proteolytic acti- vation of pro-macrophage-stimulating protein by hepsin [J]. Mol Cancer Res, 2011, 9:1175-1186.
  • 9Mosquera JM, Perner S, Genega EM, et al. Characteriza- tion of TMPRSS2-ERG fusion high-grade prostatic intraepi- thelial neoplasia and potential clinical implications [ J ]. Clin Cancer Res, 2008, 14:3380 -3385.
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同被引文献34

  • 1Lee JW, Yong Song S, Choi J J, el al. Increased expression of matriptase is associated with histopathologic grades of cervical neoplasia[J]. Hum Pathol, 2005, 36(6): 626-633.
  • 2Uhland K, Siphos B, Arkona C, et al. Use of IHC and newly designed Matriptase inhibito to elucidate the role of Matriptase in pancreatic ductal adenarcinoma[ J]. Int J Oncol, 2009, 35 ( 2 ) : 347-357.
  • 3Shi YE, Torri J, Yieh 1., et al. Identification and characterization of a novel matrix-degrading protease from hormone-dependent human breast cancer cells[ J ]. Cancer Res, 1993, 53(6) : 14-09-1415.
  • 4Saleem M, Adhami VM, Zhong W, et al. A novel biomarker for staging human prostate adenoearcinoma: overexpssinn ft matriptase with concomitant Loss of its inhibitor, hepatocyte growth factor activator inhibitor-1 [ J ]. Cancer Epidemiolo[,w Biomarkers Prey, 2006, 15 ( 2 ) : 217-227.
  • 5Tsai WC, Sheu LF, Chao YC, et al. Decreased matriptase/HAI- 1 ratio in advanced colorectal adenocarcinoma of Chinese patients [J]. Chin J Physiol, 2007, 50(5) : 225-231.
  • 6Mukai S, Yorita K, Kawagoe Y, et al. Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis [ J ]. Human cell, 2014,28(1 ) : 44-50.
  • 7Kosa P, Szabo R, Molinolo AA, et al. Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-assm.iated colon carcinogenesis [ J ]. Oncogene, 2012, 31 ( 3:2 ) : 3679-3695.
  • 8Sales KU, Masedunskas A, Bey AL, et al. Matriptase initiates activation of epidernval pro-kallikrein and disease onsel in a mouse model of Netherton syndrome [ J ]. Nat (.enet, 2010, 42 ( 8 ) : 676-683.
  • 9Gray K, Elghadban S, Thongyoo P, et al. Potent and specific inhibition of the biological activity of the type-II transmembranc serine proteasc matriptase by the cyclic microprotein MCoTI-II [J]. Thromb Haemost, 2014, 112(2) :402-411.
  • 10Suzuki M, Kobayashi H, Kanayanm N, et al. Inhibition of tumor invasion by genomie down-regulation of Matriptase through suppression of activation of receptor-bound pro-urokinase [ J]- J Biol Chem, 2004, 279( 15): 14899-14908.

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基础医学与临床
2013年 第7期

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