登革病毒样颗粒疫苗的研究现状

Review of study on Dengue virus-like particles vaccine

登革病毒引起的疾病是一种严重威胁人类健康的蚊媒性急性传染病。但至今仍没有获批准的疫苗可用。近年,一种新的病毒样颗粒(VLPs)能使免疫小鼠产生中和性抗体和持久、特异的T淋巴免疫记忆细胞。VLPs克服了传统疫苗的很多不足,具有较大应用潜力。

The infection caused by Dengue virus is an acute life-threatening mosquito-borne infectious disease. So far, an effective and safe vaccine for dengue is not yet available. Recently a new virus-like particles vaccine was developed which induces the vaccinated mice to produce neutralizing antibody, and long-lasting virus-specific mem- ory T lymphocytes. What more, it also can be widely explored by using yeast expression system. Its special priori- ties make it become a hopeful ideal dengue vaccine.