方解石制备碳酸磷灰石骨替代材料的研究

Studies on Fabrication of Carbonate Apatite Bone Substitute by Treatment of Calcite

目的:在低温条件下用方解石制备具有良好机械性能与低结晶性的碳酸磷灰石团块。方法:将氢氧化钙团块碳酸化生成方解石团块,浸泡于60℃、1mol/L的磷酸二氢钠盐溶液中14d,并对处理过程中各时间点的样本进行了抗拉强度测试、X线衍射分析、傅立叶变换红外线分析、扫描电子显微镜观察及碳酸含量、钙磷比等理化性能检测。结果:经过磷酸化处理,方解石逐渐向低结晶性B型碳酸磷灰石转化,并在7d后基本完成。DTS值不断增强,并最终达到(6.28±1.58)MPa;钙磷比与碳酸含量均接近于人骨。结论:通过方解石团块的磷酸盐溶液处理可在低温下简单合成具有良好机械性能的低结晶性B型碳酸磷灰石团块,并有望于应用在口腔临床中骨缺损的骨再建修复。

Objective： To fabricate carbonate apatite monolith with adequate mechanical strength and low crystalli- ty at lower temperature. Methods： Calcite monolith prepared by carbonation of Ca（OH）2 monolith was treated in 1 mol/1 NaH2PO4 solution at 60℃. Diametral tensile strength （DTS） were examined. X--ray diffraction analysis （XRD）, Fourier transform infrared （FT--IR） spectroscopy studies and SEM observation were performed. Results： Calcite transformed into B--type carbonate apatite with time, and almost completed after treated for 7 days. The DTS value was 6. 28-1- 1. 58MPa for 14 days. Molar Ca/P ratios and carbonate contents were similar to those of bone. Conclusion： Low--crystalline B--type carbonate apatite monolith with adequate strength can be easily fabrica- ted by phosphation of calcite, and be regarded as a promising bone reconstruction material for bone defect in oral clinical.