RyR2相关心脏性猝死的研究进展

Research progression of RyR2-related sudden cardiac death

雷诺定受体2(ryanodine receptor 2,RyR2)是心肌细胞肌浆网上主要的钙释放通道,主要参与心肌的兴奋收缩耦联过程,其基因突变及调控异常可导致心肌舒张期钙漏引起心律失常,甚至猝死。本文重点综述RyR2基因突变及调控异常引起心脏性猝死的机制,并对以后的研究提出建议,旨在为心脏性猝死的法医学诊断提供一种新的思路。

Ryanodine receptor 2 （RyR2） is a primary calcium release channel on sarcoplasmic retieulum of cardiocytes to provide the major source of calcium required for cardiac muscle excitation contraction （EC） coupling. Arrhythmia, or sudden death may happen due to the calcium leakage that caused by the gene mutation and dysregulation of RyR2. In this paper, mechanism of sudden cardiac death caused by gene mutation and abnormal regulation of RyR2 was reviewed. Moreover, some suggestions were presented for further research to provide a new thought for the diagnosis of sudden cardiac death in forensic science.