两种麻醉方法对巴马小型猪麻醉效果比较

Comparison on Anesthetic Effect of Intravenous Pentobarbital Sodium or Isoflurane Anesthesia in Mini-pig

目的对小型猪戊巴比妥钠静脉麻醉与异氟烷吸入麻醉的麻醉效果进行对比分析。方法将10头巴马小型猪随机分为两组，分别用戊巴比妥钠静脉麻醉与异氟烷吸入麻醉，记录麻醉检测指标。结果两组小型猪的麻醉时间以及不良反应率均无显著性差异（P〉0．05），而麻醉起效时间、术后苏醒时间以及术中躁动例数差异显著（P〈0．05）。两组实验组在平均动脉压（MAP）、心率（HR）等指标方面，对比差异显著（P〈0．05），而在脉搏血氧饱和度（SPO2）、PH酸碱程度值等指标差异不显著（P〉0．05）。结论戊巴比妥钠组需在实验过程中添加麻醉剂量，而异氟烷吸入麻醉组麻醉起效快，效果良好，苏醒迅速，适合各种要求的实验操作。

Objective To observe the anesthetic effect of pentobarbital sodium iv or isoflurane anesthesia on mini-pig. Methods A total of 10 healthy Bama mini-pigs were equally randomized into two groups. One group was administered with pentobarbital sodium intravenously,and the other group was administered with isoflurane. Changes in narcotic indicators were observed. Results There was no significant difference in the number, body weight, anesthesia performing hours, the adverse reaction rate, SPO2 and pH value between the two groups （P〉0.05）, but both groups had significant difference in the onset time of anesthesia, postoperative recovery time, the number of cases of intraoperative restlessness, MAP and HR （P〈0.05） between the two groups. Conclusion Anesthetic dose of sodium pentobarbital needs to be added during the experiment, while isoflurane anesthesia has better postoperative analgesic effect and less side effects, being a safe and effective analgesic option for different experiments.