2型糖尿病患者人体成分与神经传导速度的相关性分析

Correlation between body composition and nerve conduction velocity in patients with type 2 diabetes mellitus

目的分析2型糖尿病患者人体成分与神经传导速度的相关性。方法选取105例2型糖尿病患者作为研究对象,使用身体成分分析仪和肌电诱发电位仪分别测定人体成分相关参数(体质量指数、体脂肪率、肌肉率和体内水分比率等)及神经传导速度相关电生理指标(运动神经传导速度、运动末端潜伏期、复合肌肉动作电位波幅、感觉神经传导速度、感觉神经动作电位的潜伏期和波幅等),分析两者的相关性。结果体脂肪率与尺神经运动和感觉神经传导速度、腓总神经运动神经传导速度呈正相关,与尺神经、腓浅神经感觉神经动作电位的潜伏期及腓总神经运动末端潜伏期呈负相关,与腓总神经复合肌肉动作电位波幅呈负相关。肌肉率与尺神经、腓浅神经感觉神经动作电位的潜伏期、腓总神经运动末端潜伏期及腓总神经复合肌肉动作电位波幅呈正相关,与尺神经运动和感觉神经传导速度及腓总神经运动神经传导速度呈负相关。体内水分比率与尺神经、腓浅神经感觉神经动作电位的潜伏期呈正相关,与尺神经感觉神经传导速度呈负相关。体质量指数、腰围与正中神经感觉神经动作电位的波幅及胫神经复合肌肉动作电位的波幅呈负相关。结论体质量指数、腰围、体脂肪率、肌肉率和体内水分比率等可能是影响神经传导速度的重要因素。

Objective To investigate the correlation between body composition and nerve conduction velocity in patients with type 2 diabetes mellitus. Methods One hundred and five patients with type 2 diabetes mellitus were enrolled, body composition related parameters including body mass index, body fat percent, body muscle percent and body water percent were measured by body composition analyzer, nerve conduction velocity related parameters including motor nerve conduction velocity, distal motor latency, amplitude of compound muscle action potential, sensory nerve conduction velocity, latency and amplitude of sensory nerve action potential were determined, and the correlation between body composition and nerve conduction velocity was explored. Results Body fat percent was positively correlated with nerve conduction velocity of motor-sensory ulnar nerve and motor peroneal nerve, and negatively correlated with distal latency of sensory ulnar nerve, sensory superficial peroneal nerve, motor peroneal nerve and motor amplitude of peroneal nerve. Body muscle percent was positively correlated with distal latency of sensory ulnar nerve, sensory superficial peroneal nerve, motor peroneal nerve and motor amplitude of peroneal nerve, and negatively correlated with nerve conduction velocity of motor-sensory ulnar nerve and motor peroneal nerve. Body water percent was positively correlated with distal latency of sensory ulnar nerve and sensory superficial peroneal nerve, and negatively correlated with nerve conduction velocity of sensory ulnar nerve. Body mass index and waist circumference were negatively correlated with sensory amplitude of median nerve and motor amplitude of tibial nerve. Conclusion Body mass index, waist circumference, body fat percent, body muscle percent and body water percent may be important influencing factors of nerve conduction velocity.