醛脱氢酶超家族研究进展

Research progress of aldehyde dehydrogenase superfamily

醛类物质在体内是高度活跃的一类分子,体内多种酶系统参与它们的代谢,其中最重要的酶之一就是醛脱氢酶(ALDH)超家族,该家族由一系列催化醛类物质氧化的NAD(P)+依赖的酶组成。该文综述了目前已知的人ALDH超家族各成员的研究进展,对其病理生理意义作了较为详细的阐述,将为比较人ALDH家族各成员的功能以及ALDH家族在肿瘤发生和发展过程中的作用提供有用的信息。

Aldehydes are highly reactive molecules. A lot of enzyme systems participate in the metabolism of aldehydes, and one of the most important enzyme systems is aldehydes dehydrogenase （ALDH） superfamily, which is composed of NAD （P） ＋-dependent enzymes that catalyze aldehyde oxidation. This paper presents a review of what is currently known about each member of human ALDH superfamily, including the pathophysiological significance of these enzymes, in hopes of providing information for future studies on comparison of roles among ALDH members and roles of ALDH superfamily in development of cancers.