胃癌实验动物模型的研究概况

Experimental animal model of gastric cancer: an overview of current research

胃癌是最常见的恶性肿瘤之一,故建立可靠的胃癌动物模型对于探明胃癌的病因、发病机制及防治药物的研究均具有重要意义。目前,根据不同的研究水平及研究目的,胃癌动物模型可分为长期诱导型、快速移植型及其他特殊模型等,本文就胃癌动物模型的动物选择、造模方法、适用范围等的研究现状进行综述。

Stomach cancer is one of the most common malignant tumors, so the establishment of a reliable animal model of this disease has important significance in elucidating its causes and pathogenesis as well as screening the prevention and treatment drugs. At present, the animal models of gastric cancer, according to the level and purpose of study, are classified into long-term induction model, rapid xenograft tumor formation model and other specific models. This paper overviews the current status of the available animal models with regard to the animal selection, creation methods, and scope of application, etc.