90例老年胃间质瘤患者手术治疗及预后分析

Clinicopathological Charactersistics and Prognostic Factors of 90 Erderly Patients with Gastric GIST

目的分析老年胃间质瘤的临床特点,探讨影响其预后的临床因素。方法回顾性分析2000年1月2011年1月期间在中国医学科学院肿瘤医院接受手术治疗并经病理证实的90例老年胃间质瘤患者的临床资料,统计分析影响其预后的因素。结果 90例患者均接受手术切除,随访率87.0%。其1、3、5年总体生存率分别为79.7%、50.6%和32.9%;1、3、5年无进展生存率为75.9%、49.4%和32.9%。单因素分析影响老年胃间质瘤术后无疾病进展生存时间(PFS)和总生存时间(OS)的因素均为:肿瘤大小、肿瘤坏死、核分裂象和NIH危险度分级标准。结论老年胃间质瘤患者总体预后欠佳。肿瘤大小、肿瘤坏死、核分裂像和NIH危险度分级标准是影响老年胃间质瘤患者术后预后的危险因素。

Objective To analysis the clinical and pathological characteristics of gastrointestinal stromal tumors of the stomach in erderly patients and explore associated prognostic factors. Methods Ninety erderly gastric GISTs patients confirmed pathologically were ineluded from 2000 to 2011. Their clinical datas were retrospectively analyzed. Results The followup rate was 82. %. The overal survival （OS） of 1,3 and 5 years were 79.7% ,50.6% and 32.9% , respectively. The progression free survival （PFS） of 1,3 and 5 years were 75.9% ,49.4% and 32.9% , respectively. Single factor survival analysis showed that OS and PFS had significant association with tumor size, tumor necrosis, mitotic index and NIH risk group. Conclusion Elderly patients with gastric stromal tumor have poor prognosis than others. Tumor size, tumor necrosis, mitotic index and NIH risk group are potential prognositic factor of gastric GISTs.