双源CT对糖尿病前期患者冠状动脉病变筛查的临床意义

Soreening the Impaired Coronary Artery in Subjects with Impaired Glucose Regulations by DSCT

目的探讨糖尿病前期患者不同血糖水平对冠状动脉病变的影响。方法选择糖尿病前期患者及正常对照组共280例,根据血糖水平分为4组,单纯空腹血糖受损组(I-IFG)、单纯糖耐量低减组(I-IGT)、混合糖调节受损组(IFG/IGT)、糖调节正常组(NGT),分别进行冠状动脉双源CT(DSCT)扫描检查冠状动脉病变的数目及程度,分析其与血糖水平的相关性。结果无论是冠状动脉狭窄病变支数及程度I-IGT组与I-IFG组、I-IGT组及NGT组、IFG/IGT组与NGT组、IFG/IGT间与I-IFG组均存在统计学意义的区别(P<0.05),而I-IFG组与NGT组,I-IGT组与IFG/IGT组比较无统计学意义(P>0.05)。结论餐后血糖的早期升高可能是冠状动脉病变的独立危险因素。

Objective To investigate the number and the extent of the impaired coronary artery in nondiabetic subjects with different categories of impaired glucose regulations by DSCT. Methods A total of 280 subjects had undergone DSCT scan. Subjects were classified according to 75g oral glucose torelanee test results： isolated impaired fasting glucose （ I - IFG） ; isolated impaired glucose tolerance （ I - IGT） ; combined IFG and IGT （IFG/IGT） ; normal glucose tolerance （NGT）. Results There were significant differences between I - IGT and I - IFG, I - IGT and NGT, IFG/IGT and NGT, IFG/IGT and I - IFG （ P 〈 0. 05 ） , whileas I - IFG and NGT, I - IGT and IFG/IGT had no significant difference, （P 〉 0.05）. Conclusion The early increased postgrand glucose maybe an isolated risk facter for coronary artery disease.