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IgD型多发性骨髓瘤的实验室及临床特点分析 被引量:3

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摘要 目的探讨IgD型多发性骨髓瘤(MM)的骨髓细胞形态学特点及其预后。方法采集100例初发MM患者血清进行免疫电泳,根据结果将其分为3组,分别为IgG型71例,IgA型20例,IgD型9例。对9例IgD型形态学特点进行回顾性分析,并与IgG型和IgA型进行比较。结果 IgD型原始和幼稚浆细胞百分比均明显高于IgG和IgA型(均<0.05)。成熟浆细胞百分比在3种类型中差异无统计学意义(>0.05)。生存分析曲线提示IgD型MM患者生存时间明显短于IgG和IgA型MM患者(<0.01)。结论 IgD型MM的原始幼稚浆细胞百分比较高,预后较差。
机构地区 宁波市第一医院
出处 《现代实用医学》 2013年第6期677-678,共2页 Modern Practical Medicine
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  • 1Jancelewicz Z, Takatsuki K, Sugai S, et al. IgD multiple myeloma. Reviewof 133 cases[J]. Arch Intern Med, 1975,135(1):87-93.
  • 2Blade J, Lust JA, Kyle RA. Immunoglobulin D multiple myeloma: presenting features, response to therapy, and survival in a series of 53 cases[J]. J Clin Oncol, 1994,12(11):2398-2404.
  • 3Shimamoto Y, Anami Y, Yamaguchi M. A new risk grouping for IgD myeloma based on analysis of 165 Japanese patients[J]. Eur J Haematol, 1991,47(4):262-267.
  • 4Blade J, Lust JA, Kyle RA. Immunoglo-bulin D multiple myeloma: presenting features, response to therapy, and survival in a series of 53 cases[J]. J ClinOncol, 1994,12(11 ):2398-2404.
  • 5Fritz E, Ludwig H, Kundi M. Prognostic relevance of cellular morphology in multiple myeloma[J]. Blood, 1984,63(5): 1072-1079.

同被引文献28

  • 1周振海,罗绍凯,李娟,李小银,李幼姬,洪文德.多发性骨髓瘤本周蛋白基因可变区特点与肾小管功能损害的关系[J].中华内科杂志,2005,44(9):677-680. 被引量:7
  • 2Blade J,Lust JA,Kyle RA.Immunoglobulin D multiple myeloma:presenting features,response to therapy,and survival in a series of 53 cases[J].J Clin Oncol,1994,12:2398-2404.
  • 3Zagouri F,Kastritis E,Symeonidis AS,et al.Immunoglobulin D myeloma:clinical features and outcome in the era of novel agents[J].Eur J Haematol,2014,92:308-312.
  • 4Sinclair D.IgD myeloma:clinical,biological and laboratory features[J].Clin Lab,2002,48:617-622.
  • 5Shimamoto Y,Anami Y,Yamaguchi M.A new risk grouping for IgD myeloma based on analysis of 165 japanese patients[J].Eur J Haematol,1991,47:262-267.
  • 6Zhang L,Qi JY,Qi PJ,et al.Comparison among immunologically different subtypes of 595 untreated multiple myeloma patients in northern china[J].Clin Lymphoma Myeloma Leuk,2010,10:197-204.
  • 7Wechalekar A,Amato D,Chen C,et al.IgD multiple myeloma a clinical profile and outcome with chemotherapy and autologous stem cell transplantation[J].Ann Hematol,2005,84:115-117.
  • 8Kim MK,Suh C,Lee DH,et al.Immunoglobulin D multiple myeloma:response to therapy,survival,and prognostic factors in 75 patients[J].Ann Oncol,2011,22:411-416.
  • 9Chong YP,Kim S,Ko OB,et al.Poor outcomes for IgD multiple myeloma patients following high-dose melphalan and autologous stem cell transplantation:a single center experience[J].J Korean Med Sci,2008,23:819-824.
  • 10陈字,顾英,张弢.多发性骨髓瘤单克隆免疫球蛋白型别的检测及分析[J].医学临床研究,2008,25(12):2140-2141. 被引量:4

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