白芍总苷与辛伐他汀对腹膜纤维化大鼠腹膜功能的影响

Effect of Total Glucosides of Paeony and Simvastatin on Rat Peritoneal Function of Peritoneal Fibrosis

目的:比较白芍总苷与辛伐他汀对腹膜纤维化大鼠腹膜功能的影响。方法:选用健康SD大鼠32只,随机分为4组,每组8只,分别为:空白组、模型组、辛伐他汀组、白芍总苷组。用持续4.25%含糖透析液和间断脂多糖腹腔注射进行腹膜纤维化造模。辛伐他汀组每日给予辛伐他汀20mg.kg-1.d-1灌胃,白芍总苷组每日给予白芍总苷灌胃200mg.kg-1.d-1;实验第30天结束后检测腹膜功能及测量腹膜厚度。结果:模型组的腹膜厚度最厚,腹膜超滤量最差,与其他3组有显著性差异(P<0.05)。辛伐他汀组、白芍总苷组的腹膜厚度及腹膜超滤量与空白组相比,有显著性差异(P<0.05)。辛伐他汀组腹膜厚度与白芍总苷组相比,有显著性差异(P<0.05)。辛伐他汀组超滤量与白芍总苷组相比,无显著性差异(P>0.05)。结论:白芍总苷和辛伐他汀均可一定程度保护腹膜,预防腹膜纤维化的发生。

Objective: To compare the effect of total glucosides of paeony and simvastatin on the rat peritoneal function of peritoneal fibrosis.Methods: 32 healthy SD rats were selected and randomly divided into 4 groups,8 rats per group,i.e.blank group,model group,simvastatin group,total glucosides of paeony group.Peritoneal fibrosis models were made with 4.25% of dialysate and intermittent lipopolysaccharide intraperitoneal injection.The simvastatin group was daily administered with 20 mg.kg-1.d-1 gavage of simvastatin and the total glucosides of paeony group were daily fed with total glucosides of paeony gavage for 200 mg.kg-1.d-1.The peritoneal thickness was measured 13 days later.Results: The peritoneal thickness of the model group was the thickest and the peritoneal ultrafiltration volume was the worst,having significant difference(P < 0.05),compared with the other three groups.The peritoneal thickness and the peritoneal ultrafiltration volume of both the simvastatin group and the total glucosides of paeony group had significant difference(P < 0.05),compared with that of the blank group.The comparison of the simvastatin group and the total glucosides of paeony group showed significant difference(P < 0.05).The ultrafiltration volume of the simvastatin group had no significant difference(P > 0.05) compared with that of the total glucosides of paeony group.Conclusion: The total glucosides of paeony and simvastatin can partly protect the peritoneal and prevent the occurrence of the peritoneal fibrosis