黄蛭方联合西医治疗糖尿病肾病临床观察

Clinical observation of Huangzhi prescription combined with western medicine on diabetic nephropathy

目的观察黄蛭方联合西医治疗糖尿病肾病(DN)的临床疗效。方法将110例DN患者随机分为2组,对照组54例予西医常规治疗,治疗组56例在对照组治疗基础上加黄蛭方。2组均3个月为1个疗程,共治疗2个疗程。检测2组治疗前后空腹血糖(FPG)、糖化血红蛋白(HbAlc)、血脂[包括总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)]及肾功能指标血肌酐、尿酸、β2-微球蛋白(β2-MG)、24 h尿蛋白定量、血白蛋白变化情况。结果治疗组总有效率89.3%,对照组总有效率68.5%,2组总有效率比较差异有统计学意义(P<0.01),治疗组临床疗效优于对照组。2组治疗后FPG、HbAlc、TC、HDL-C、LDL-C及肾功能各指标均较本组治疗前明显改善(P<0.01,P<0.05),且治疗组FPG、LDL-C、β2-MG及24 h尿蛋白定量下降程度优于对照组(P<0.05)。结论黄蛭方可明显降低DN患者血糖及血脂水平,改善肾功能,疗效确切。

Objective To observe the effect of Huangzhi prescription combined with western medicine on diabetic nephropathy（DN）.Methods 110 patients with DN were randomly divided into two groups.54 cases in control group received conventional western medicine therapy.56 patients in treatment group were treated by Huangzhi prescription on the basis of control group treatment.The therapeutic course was three months in two groups.The changes of FPG,HbA1c,TC,TG,LDL-C,HDL-C,serum Cr,uric acid,β2-MG,24 h urine protein and blood albumin were measured before and after treatment.Results The total effective rate in treatment group（89.3%） was superior to that in control group（68.5%,P0.05）.FPG,TC,HDL-C,LDL-C and renal function indexes after treatment were improved as compared with those before treatment in two groups（P0.01,P0.05）.The decreases of FPG,LDL-C,β2-MG and 24 h urine protein in treatment group were superior to those in control group after treatment（P0.05）.Conclusion Huangzhi prescription can obviously reduce the levels of blood sugar and blood lipid in patients with DN,improve renal function,the effect is definite on DN.