金昌地区老年患者下呼吸道感染铜绿假单胞菌耐药性变迁分析

Changes of drug resistance of Pseudomonas aeruginosa isolated from old patients with lower respiratory tract infections in Jinchang

目的了解金昌地区老年患者医院下呼吸道感染铜绿假单胞菌(PAE)的耐药性变迁。方法收集分离自金昌地区3所综合医院2010年1月至2012年10月住院老年下呼吸道感染患者的PAE菌株,采用K-B法进行药敏试验。结果 3年分离的326株PAE对12种常用抗菌药物的耐药率总体呈上升趋势,对美洛培南的耐药率最低,为19.0%,对氨曲南的耐药率最高,为56.1%。对头孢他啶的耐药率上升最为明显,其次为头孢吡肟、氨曲南等。共检出泛耐药菌株13株,占3.7%。结论金昌地区老年患者医院下呼吸道感染PAE的耐药性严重,总体呈逐年上升趋势,应根据药敏试验结果合理选择抗菌药物,防止泛耐药菌的产生。

Objective To investigate the changes of drug resistance of Pseudomonas aeruginosa(PAE) isolated from old patients with lower respiratory tract infections of PAE in Jinchang.Methods PAE strains,isolated from old patients with lower respiratory tract infections of PAE in three hospitals of Jinchang from Jan.2010 to Oct.2012,were collected to be detected for drug resistance by using K-B method.Results 326 strains of PAE were collected,drug resistances of which to 12 kinds of antibiotics were gradually ascending.Resistant rate to meropenem was the lowest(19.0%) of all antibiotics,whereas to aztreonam was the highest(56.1%).The increasing trend of drug resistant rate to ceftazidime was the most obvious,followed with cefepime,aztreonam and so on.13 strains of pan-drug resistant strains were isolated,accounting for 3.7%.Conclusion Drug resistance of PAE,causing lower respiratory tract infections in old patients in Jinchang,might be serious,with increasing tendency.It could be very important to choose the effective antibiotics according to the result of antibiotic sensitivity test so as to prevent the pan-drug resistant strains.