TC及ALT在他汀类药物治疗脑出血患者预后判断中的应用价值分析

Significance of TC and ALT for the prognosis of cerebral hemorrhage patients treated with statins

目的探讨总胆固醇(TC)及丙氨酸氨基转移酶(ALT)与他汀类药物治疗脑出血患者预后的相关性。方法根据TC、ALT水平将254例脑血管病患者分为TC增高组、ALT增高组及TC、ALT同时增高组。采用χ2检验分析各数据与疾病预后的关系;采用单因素方差分析比较各组间年龄差异;采用一元线性相关与回归分析他汀类药物改善脑出血患者预后的可行性。结果各研究组间发病率及年龄比较差异有统计学意义(P<0.05);一元线性回归显示他汀类药物可降低TC、提高高密度脂蛋白胆固醇(HDL-C)水平,二者存在线性相关;他汀类药物治疗后,患者ALT水平升高(P<0.05)。结论 TC及ALT增高提示脑出血患者预后不良,但不同年龄人群诊断依据有所差别。他汀类药物可降低TC、提高HDL-C水平,有助于改善脑出血患者预后,且二者存在线性相关。

Objective To investigate the significance of total cholesterol （TC） and alanine aminotransferase （ALT） for the prognosis of cerebral hemorrhage patients treated with statins. Methods According to TC and ALT level,254 patients with cerebrovascular disease were divided into increased TC group, increased ALT group and in- creased TC,ALT group. Chi-Square analysis was used to compare test data. Age characteristics of three groups were analyzed by ANOVA test. Linear regression and correlation analysis were performed to analyz the infection of statins on the prognosis of patients. Results There were significant differences among the three groups,but without signifi- cant difference between increased TC and ALT level for the prognosis of cerebral hemorrhage. Statins could increase high density lipoprotein cholesterol （HDL-C） level and improve the prognosis of patients. Conclusion increasing could indicate poor prognosis in patients with cerebral hemorrhage, but the diagnosis should difference of age. Statins could reduce TC and increase HDL-C level,so as to improve the prognosis of cerebral hemorrhage. TC and ALT based on the patients with