呼吸系统疾病住院患者抗菌药物应用状况分析

Application of antimicrobial drugs among hospitalized patients with disease of respiratory system

目的分析该院呼吸系统疾病住院患者抗菌药物应用是否合理。方法收集130例呼吸系统疾病住院患者病历资料,对抗菌药物用药频率、用药总量等指标进行统计分析。结果 130例患者中仅1例患者没有使用抗菌药物,抗菌药物使用率为99.23%,抗菌药物总使用例次为466例,使用例次占前3位的是喹诺酮类(33.47%)、三代头孢(15.02%)和青霉素酶抑制剂复合制剂(14.38%)。阿莫西林克拉维酸钾、头孢吡肟、头孢呋辛、美洛西林和左氧氟沙星药物利用指数大于1,使用不合理;头孢唑肟、阿奇霉素、哌拉西林/他唑巴坦、帕珠沙星和头孢替安药物利用指数小于1,使用较为合理。结论该院呼吸系统疾病住院患者抗菌药物应用较为因素,但仍应加强对临床医生的培训,实现抗菌药物有效、安全、合理应用。

Objective To explore the application status of antimicrobial in hospitalized patients with disease of respiratory system. Methods Medical records of 130 patients with disease of respiratory system were collected,and administration frequency of antimicrobial, total administration amount and other indicators were statistically ana- lyzed. Results There was only one case,among 130 patients,did not use antimicrobial drugs. The rate of antimicrobi- al application was 99.23%. The total cases with antimicrohial administration was 466, and the first three frequently used antimicrobial drugs were fluoroquinolones （33.47%）,third generation cephalosporins （15.02%） and penicillin enzyme inhibitor complex preparation （14.38%）. The drug utilization indexes of amoxieillin and clavulanate potassi- um, cefepime, cefuroxime, mezlocillin and levofloxacin were more than 1,indication unreasonable usage. The drug uti- lization indexes of ceftizoxime, azithromycin, piperaeillin/tazobactam, pazufloxacin and cephalosporin were less than 1 ,indicating reasonable usage. Conclusion The usage of antibacterial drugs might be reasonable in patients with dis- ease of respiratory system, but the training about antibacterial drug application knowledge should also be strength- ened for more effective, safe and reasonable usage of antibacterial drugs.