血浆脑钠肽与瓣膜置换术后心脏复跳的关系

The relationship of preoperative serum brain natriuretic peptide level and cardiac resuscitation after cardiac valve replacement

目的探讨血浆脑钠肽（BNP）的水平对瓣膜置换术后心脏复跳的预测效果。方法收集83例行心脏瓣膜置换术患者病历资料进行回顾性分析，根据心脏是否自动复跳分为自动复跳组（32例）及电击复跳组（51例），比较2组术前血浆BNP水平，对心脏复跳的电击次数及血浆BNP水平进行相关回归分析。结果自动复跳组和电击复跳组术前BNP分别为（226±130）和（628±411）ng／L，组间差异有统计学意义（P〈0．01）。Spearman相关分析表明术前血浆BNP水平与术后心脏电击次数呈正相关（r=0．8055，P=0．000）。结论术前血浆BNP的水平可以预测瓣膜置换术后心脏复跳的难易，对于高BNP水平患者应加强术前心功能的纠治。

Objective To discuss the predictive effect of serum brain natriuretic peptide （BNP） level on cardiac resuscitation post cardiac valve replacement. Methods Eighty-three patients underwent cardiac valve re- placement were divided into to groups according to whether the heart resuscitate automatically or not. The materials of the two groups were analyzed. Then, correlation and regression analysis were performed between the level of BNP and electric shock resuscitation times in all the 83 patients. Results The level of BNP pre-operation was lower in automatic resuscitation group than that in electric shock resuscitation group [ （226±130）ng/L vs （628 ± 411 ）ng/L, P 〈 0.01 ]. A positive correlation between BNP level and cardiac shock resuscitation times was found（ Spearman r = 0. 8055, P = 0. 000）. Conclusions Preoperative serum BNP level can predict the difficulty of cardiac resuscitation after cardiac valve replacement surgery. Correction of preoperative cardiac dysfunction in patients with high BNP lev- el should be strengthened.