辛芩雾化剂对支气管哮喘患者肺功能及其生命质量的影响

Effects of Xinqin alevaire on lung function and the quality of life in patients with bronchial asthma

目的探讨辛芩雾化剂对支气管哮喘患者肺功能及其生命质量的影响。方法124例支气管哮喘患者按随机数字表随机分为对照组（60例）和观察组（64例）。2组均予同时配合抗炎、抗过敏、止咳、化痰等对症治疗。在此基础上，观察组加用辛芩雾化剂（3级：辛芩雾化剂30m1；2级：辛芩雾化剂15ml；1级：辛芩雾化剂15ml）超声雾化吸入，对照组加用丙酸倍氯米松气雾剂（3级：200～300峭；2级：100～200μg；1级：100—200μg）吸入，2组中2、3级患者均加用B：受体激动剂吸入，于治疗3个月后评估临床症状、征候积分、疗效及生命质量评分。结果观察组和对照组总有效率比较，差异无统计学意义[96．9％（62／64）比100．0％（60／60）]（P〉0．05）；观察组和对照组治疗后3个月测得的第1秒用力呼气容积占预计值百分比（FEV1％）、最大呼气流量（PEF）、最大呼气流速（PEFR）值均较治疗前明显改善[观察组：FEV1％为（87±4）％比（70±4）％，PEF为（350±40）L／min比（316±35）L／min，PEFR为（13．4±2．4）％比（18．3±3．0）％；对照组：FEV1％为（86±4）％比（71±4）％，PEF为（346±37）L／min比（326±37）L／min，PEFR为（14．3±2．1）％比（19．7±2．9）％]（均P〈0．05）。但2组治疗后3个月测得的FEV1％、PEF、PEFR值比较差异无统计学意义（P〉0．05）。观察组生命质量评分总分[（62±6）分]明显优于对照组[（82±7）分]（P〈0．05）。结论辛芩雾化剂吸入替代激素治疗能改善支气管哮喘患者肺功能及其生命质量，其治疗成人支气管哮喘安全、有效。

Objective To explore the effects of Xinqin alevaire on lung function and quality of life in pa- tients with bronchial asthma. Methods Totally 124 patients with bronchial asthma were randomly divided into ob- servation group（ n =64 ）and control group（ n = 60）. Two groups were given symptomatic treatment including anti- inflammatory, anti-allergic, stop coughing and eliminate sputum. Control group was inhaled becotide Spray and ob- servation group was given Xinqin alevaire （30 ml or 15 ml）, based on the above-mentioned syrup （tomatic treatment. After treatment the clinical efficacy pulmonary function and quality of life imstruments were observed in two groups. Results There were no statistical differences between observation group and control group in the total effective rate. After treatment, the forced expiratory volume in 1 second accounts （ FEV1% ）, percentage expected maximum ex- piratory flow （PEF） and the maximal expiratory flow rate （PEFR） all changed [ observation group： FEV1% （87 ± 4）% vs（70 ±4）%, PEF（350 ±40） L/min vs（316 ±35）L/min, PEFR（13.4 ±2.4）% vs（18.3 ±3.0）% ; con- trol group ： FEV1% （ 86 ±4） % vs （71 ± 4 ） %, PEF （ 346 ±37 ） L/min vs （ 326 ± 37 ） L/min, PEFR （ 14.3 ± 2.1 ） % vs（ 19.7 ± 2.9）% ] and the quality of life was significantly improved than that before treatment in two groups（P 〈 0.05）. Conclusion Xinqin alevaire can significantly improve lung function and the quality of life in patients with bronchial asthma.