RA伴贫血患者治疗前、后网织红细胞参数变化

The changes of reticulocyte indices in rheumatoid arthritis patients with anemia

目的检测活动性类风湿性关节炎(RA)伴慢性病贫血(ACD)患者网织红细胞参数的变化及临床意义。方法采用日本Sysmex XE-2100全自动五分类血细胞分析仪,检测治疗前、后80例RA伴ACD患者和40例正常对照者的网织红细胞百分数(Ret%)、高散射光网织红细胞百分数(HFR%)、网织红细胞不成熟度(IRF),比较抗风湿药治疗前、后患者Ret%、HFR%、IRF的变化。结果治疗前Ret%、HFR%、IRF较对照组均降低;经抗风湿药治疗后Ret%、HFR%、IRF值升高,IRF值升高的程度更明显。结论 Ret参数的检测有助于了解RA伴贫血患者治疗前、后骨髓红系生长情况,IRF能够敏感地反映治疗后患者的贫血改善程度,可作为患者治疗效果监测的有效手段。

Objective To investigate the level of the changes of Ret parameters in Peripheral blood from patients with active rheumatoid arthritis with anemia.Methods Reticulocytes（Ret%）,high rescence radio（HFR%）,immature retivulocyte fraction（IRF）of peripheral blood were detected by Sysmex XE-2100 hematology analyzer.The results were compared with 40 healthy controls and 80 rheumatoid arthritis with anemia.The results of Ret%,IRF and HFR% of the rheumatoid arthritis with anemia patients were compared before and after the treatment with Resistance rheumatism medicine.Results The levels of Ret%,HFR%,IRF of the patients with active rheumatoid arthritis with anemia descended in comparison with normal control before the treatment.The level of Ret%,HFR% and IRF of the patients increased after treatment.The change of IRF was more obvious.Conclusion The detection of reticulocyte indices is favourable for observing the growth of erythrocyte bone marrow marrow in the rheumatoid arthritis with anemia before and after the treatment,IRF could be used to evaluate the degree of improvement of anemia in patients after treatment.