紫茎泽兰基芳香防蛀缓释剂的制备与性能研究

Preparation and Release Kinetics of Multi-functional Mothproofing Sustained-release Tablets Based on Eupatorium Powders as a Carrier

为了制备紫茎泽兰基芳香型防蛀缓释剂,通过可压性和开放式体外释放实验,确立了适宜在片剂中添加的吸附剂和赋形剂,并探讨了制剂组成和制备工艺条件对片剂释放性能的影响,通过药效试验测定片剂的药效。结果表明,微粉硅胶具有较好的可压性及控释作用,适宜添加在片剂中;以紫茎泽兰草粉为载体,在10MPa压力下可成功制备外形完好的紫茎泽兰基芳香防蛀缓释片剂,片剂中紫茎泽兰草粉用量可高达片剂质量的76%(m/m),且香味持留时间可达3个月以上;薰衣草香精的加入不仅能掩盖草粉的不愉悦气味,还能提高片剂的药效。本研究中芳香防蛀缓释剂的成功制备,不仅拓宽了紫茎泽兰的综合利用范围,也为国内防蛀剂市场提供了一个具有增香的多功能防蛀缓释剂。

In order to prepare the aromatic and mothproofing sustained-release tablets based on eupatorium powders, the absorbents and excipients appropriately incorporated into the tablets were selected by using compression formulation experiment and in vitro release experiment. The influence of the compositions of the tablets and formulation conditions on the release kinetics was investigated using in vitro dynamic release experiments. The efficacies of tablets were evaluated by test insects. The results showed that： Micro-silica powders appropriately incorporated into the tablets had good compressibility and controlled-release effect. The sustained-release tablets could be successfully prepared by using eupatorium powders as a carrier and the formulation pressure of 10 MPa. The obtained lavender flavor-containing eupatorium-based tablets had good appearance and the maximum amount of eupatorium powders could reach 76% （m/m） of the quality of the tablet, and the release of lavender flavor from the tablets sustained more than 3 months. The incorporation of a certain amount of lavender flavor into the tablets could not only mask the bad smell of eupatorium dry powders but also improve the mothproofing efficacy of the tablets. In this study, the aromatic and mothproofing sustained-release tablets can be successfully prepared. The obtained results can not only broadens the scope of the comprehensive utilization of eupatorium, but also provide a multi-functional mothproofing sustained-release tablets with aromatic flavor for the domestic mothproofing market.