期刊文献+

DNA倍体分析筛查宫颈及癌前病变的意义 被引量:2

The clinical value of DNA ploidy pattern analysis in screening for cervical cancer
下载PDF
导出
摘要 目的:探讨细胞DNA倍体分析在宫颈筛查中的应用.方法:宫颈糜烂患者500例,由妇科医生留取标本,用麦克奥迪(厦门)全自动细胞图像分析系统对标本行Feulgen染色后进行DNA定量分析系统自动扫描分析;对有异常者进一步作阴道镜检查或活检确诊.结果:500例中发现有异常者60例,其中1~2个异倍体细胞的36例,≥3个异倍体细胞的24例,病理检查结果显示:正常者4例,宫颈炎19例,宫颈上皮内瘤样病变CINⅠ15例,CINⅡ8例,CINⅢ 11例,宫颈癌3例,DNA倍体分析系统与病理诊断符合率为93.3%(56/60).结论:全自动DNA倍体分析系统可以作为辅助方法,对宫颈及其癌前病变早期诊断具有重要的参考价值. Objective:To observe the clinical value of DNA ploidy pattern analysis in screening for cervical cancer. Methods:500 samples from cervical erosion patients were analysed by DNA ploidy pattern analysis system. Furthermore, the abnormal of all were confirmed by histopathology.Results:60 abnormal cases were found by DNA ploidy pattern analysis system. Of these, there was one or two heteroploid cells in 36 cases and more than 3 heteroploid cells in 24. The results of histopathology diagnosis shows 19 cases of Cervicitis, 15 of cervical intraepithelial neoplasia I (CIN I ), 8 of CIN I], 11 of CIN IU, 3 of cervical cancer and 4 of normal among 60 abnormal cases. The diagnose accordance rate was 93.3% between DNA ploidy pattern analysis system and histopathology diagnosis. Conclusions:As a sumplemetary method, DNA ploidy pattern analysis system is of great value for early diagnosis of cervical cancer.
出处 《安徽卫生职业技术学院学报》 2013年第3期82-83,共2页 Journal of Anhui Health Vocational & Technical College
关键词 全自动细胞DNA倍体分析系统 宫颈癌 筛查 DNA ploidy pattern analysis system Cervical cancer Screening
  • 引文网络
  • 相关文献

参考文献5

二级参考文献23

  • 1孙小蓉,李玉兰,车东媛,晏想成,凌慧芳,凃洪章,汪键.用细胞DNA定量分析方法进行宫颈癌普查的临床研究[J].诊断病理学杂志,2005,12(1):12-16. 被引量:67
  • 2Liu S, Semenciw R, Probert A, et al. Cervical cancer in Canada: changing patterns in incidence and mortality. Int J Gynecol Cancer, 2001,11:24-31.
  • 3Guidozzi F. Screening for ovarian cancer. Obstet Gynecol Surv, 1996,51:696-701.
  • 4Wright TC, Kurman RJ, Ferenczy A. Precancerous lesions of the cervix. In: Kurman RJ, ed. Blaustein′s pathology of the female genital tract. 5th ed. New York: Springer, 2002.253-324.
  • 5Munoz N, Bosch FX. The causal link between HPV and cervical cancer and its implications for prevention of cervical cancer. Bull Pan Am Health Organ, 1996,30:362-377.
  • 6B(o)cking A, Motherby H. Assessment of cervical dysplasia with DNA image cytometry. Pathologe, 1999,20:25-33.
  • 7Haroske G, Baak JP, Danielsen H, et al. Fourth updated ESACP consensus report on diagnostic DNA image cytometry. Anal Cell Pathol, 2001,23:89-95.
  • 8Grote HJ, Friedrichs N, Pomjanski N, et al. Prognostic significance of DNA cytometry in carcinoma of the uterine cervix FIGO Stage IB and II. Anal Cell pathol, 2001,23:97-105.
  • 9Hanselaar AG, B(o)cking A, Gundlach H, et al. Summary statements on quantitative cytochemistry (DNA and molecular biology): Task Force 8. Acta Cytol, 2001,45:499-501.
  • 10Bulten J, Poddighe PJ, Robben JC, et al. Interphase cytogenetic analysis of cervical intraepithelial neoplasia. Am J Pathol, 1998,152:495-503.

共引文献92

同被引文献21

引证文献2

二级引证文献45

;
使用帮助 返回顶部