雾化吸入痰热清针剂对呼吸机相关性支气管炎的影响

THE AFFECT OF AEROSOL INHALATION OF INJECTION TANREQING ON PATIENTS WITH VENTILATOR-ASSOCIATED TRACHEOBRONCHITIS

目的针对无基础肺部感染的呼吸机相关性支气管炎(VAT)患者,观察雾化吸入痰热清针剂的治疗效果。方法将无基础肺部感染的VAT患者随机分配到治疗组和对照组,治疗组采用痰热清进行雾化,2 ml/次,每日3次;对照组采用等量生理盐水雾化,每日3次。治疗期7天,观察期3个月;比较两组患者呼吸机相关性肺炎(VAP)发生率、有创机械通气时间、入住ICU时长、死亡率等情况。结果治疗组的VAP发生率及死亡率显著低于对照组;治疗组和对照组在ICU住院日、有创呼吸机辅助通气时间等方面比较差异均无统计学意义(p>0.05)。结论对于发生VAT的无基础肺部感染患者,雾化吸入痰热清针剂能降低VAP发生率及死亡率。

Objective To evaluate the effects of Tanreqing injection on the patients with ventilator - associ- ated tracheobronchitis（VAT）. Methods The VAT patients were divided into Tanreqing injection inhalation group and control group, patients in formal group treated with Tanreqing injection inhalation, while those in control group instead with normal saline, treatment for 7 days, observed the VAT incidence rate, mortality, days of mechanical ven- tilation and average of hospital stay for 3 months. Results The incidence of VAT and mortality of treatment group was significantly lower than the control group, though the days of mechanical ventilation and average of hospital stay with no statistically significance （p 〉 0. 05）. Conclusion Tanreqing injection inhalation can reduce the incidence rate and mortality of VAT for patients with no other pulmonary disease.