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丘脑病变与记忆障碍的关系研究 被引量:2

Research of relationship between thalamic lesion and memory impairment
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摘要 目的探讨丘脑病变与记忆障碍的关系。方法给35例丘脑病变患者及30名正常对照者进行简易精神状态检查、临床痴呆评定量表检测。排除丘脑病变组中重度认知功能障碍、无明显记忆力下降及双侧丘脑病变者,其他病例和正常对照者进行临床记忆量表(CMS)检测;分别比较左、右侧丘脑病变患者及与正常对照组之间的检查结果。观察有、无记忆力障碍患者头颅CT、MRI显示的丘脑病变位置。结果丘脑病变组有重度认知功能障碍1例、记忆障碍27例(左侧丘脑病变15例,右侧丘脑病变12例),无明显记忆障碍7例。CMS评分示,左侧丘脑病变组各分项评分和总记忆商均显著低于正常对照组(均P<0.001),而右侧丘脑病变组图像自由回忆和无意义图形再认评分与正常对照组的差异无统计学意义。左侧丘脑病变组指向记忆、联想学习、无意义图形再认评分和总记忆商显著低于右侧丘脑病变组(均P<0.01)。有记忆障碍患者的丘脑病灶位于丘脑内侧或前方,而无记忆障碍患者的病灶位于丘脑外侧和后方。结论丘脑病变常引起记忆障碍,左侧丘脑病变的记忆障碍比右侧重,言语性记忆障碍较显著;丘脑病变的位置与记忆障碍有关。 Objective To study the relationship between thalamie lesion and memory impairment. Methods Thirty-five patients with thalamic lesions and 30 normal controls were detected by the Mini-Mental State Examination (MMSE) and the clinical dementia rating scale. Exclusion of patients with severe cognitive impairment,no obvious memory impairment and bilateral thalamic lesions, the other cases and normal controls were detected by clinical memory scale (CMS). The examination results of patients with left, right thalamic lesion were compared with each other and with normal control group. Thalamic lesion location detected with head CT, MRI in patients with or without memory impairment was observed. Results There were 1 case of severe cognitive dysfunction, 27 cases of memory impairment (15 cases of left, 12 cases of fight thalamie lesion) ,and 7 cases without obvious memory impairment in the thalamie lesion group. CMS score showed that each item score and the total memory quotient in the heft thalamie lesion group were significantly lower than those in the normal control group ( all P 〈 0. 001 ). While the differences of image free recall and nonsense figure recognition score between fight thalamic lesion group and normal control group were not statistically significant. The pointing to memory, associative learning, nonsense figure recognition score and total memory quotient in the left thalamic lesion group were significantly lower than those in the fight thalamie lesion group ( all P 〈 0. 01 ). The thalamic lesions of patients with memory impairment were located medially or front, while those of patients without memory impairment were located lateral and rear. Conclusions Thalamie lesions often cause memory impairment. Memory impairment induced by left thalamus lesions is more serious than that by fight thalamic lesions, particularly verbal memory impairment. Memory impairment is related with the location of thalamie lesion.
出处 《临床神经病学杂志》 CAS 北大核心 2013年第3期165-168,共4页 Journal of Clinical Neurology
关键词 丘脑病变 记忆障碍 认知功能障碍 thalamic lesion memory impairment cognitive dysfunction
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参考文献11

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