2Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention, detee tion, evaluation and treatment of high blood pressure:the JNC 7 report[J]. JAMA,2003,289(19):2560-2572.
3Ozkan Y,Ozkan E, Simsek B. Plasma total homoeysteine and eysteine levels as cardiovascular risk factors in coronary heart disease[J], lnt J Cardiol, 2002,82 (3) : 269-277.
5Li Z, Sun L, Zhang H, et al. Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetefrahydrofolate reductase gene C677T polymor phism was a risk factor for thrombotic stroke: a Multicenter Case-Control Study in China [J]. Stroke, 2003,34 (9) :2085-2090.
6Zhang W, Sun K,Chen J, et al. High plasma homoeysteine levels contribute to the risk of stroke recurrence and all cause mortality in a large prospective stroke population[J]. Clin gel (I.ond) ,2009,118(3) :187-194.
7Sun Y,Chien KL,Hsu HC,et al. Use of serum homocysteine to predict stroke, coronary heart disease and death in ethnic Chinese. 12 year prospective cohort stndy[J ]. Circ J,2009,73 (8)11423-1430.
9Yang Q, Botto LD, Eriekson JD, et al. Improvement in stroke mortality in Canada and the United States, 1990 to 2002[J]. Circulation, 2006,113(10): 1335-1343.
4WHO. CVD-Risk Management Package for low- and medium-resource settings[S]. 2002.
5MANCIA G, DE BACKER G, DOMINICZAK A,et al. 2007 Guidelines for the management of arterial hypertension:the task force for tile management of arterial hypertension of the European Society of Hypertension(ESH) and the European Society of Cardiology ( ESC ) [ J ]. Hypertension, 2007,25 ( 6 ) : 1105 - 1187.
7EMEA. Note for guidance on fixed combination medicinal products[S]. London, 1996.
8GRAHAM IM,DALY I,E,REFSUM HM,et al. Plasma homocysteine as a risk faclor for vascular disease. The European Concerted Action Project[J]. JAMA,1997,277(22) :1775 - 1781.
9KJELDSEN SE, JULIUS S, HEDNER T, et al. Stroke is more common than myocardial infarction in hypertension: analysis based on 11 major randomized intervention trials[ J]. Blood Pressure,2001,10(4) :190 - 192.
10WOLF-MAIER K,COOPER RS, BANEGAS JR,et al. Hypertension prevalence and blood pressure levels in 6 European coun tries, Canada, and the United States [ J ]. JAMA. 2003,289 ( 18 ) 2363 - 2369.
