奥美沙坦酯对轻中度高血压的降压疗效及对踝臂指数的影响

Antihypertensive effects and influence of olmesartan medoxomil tablet on mild and moderate primary hypertension and ABI

目的探讨奥美沙坦酯对轻中度高血压降压疗效及对踝臂指数的影响。方法 2011年7-11月我院收治的高血压患者120例,将其随机分为奥美沙坦组和氨氯地平组,治疗8周,检测血常规、尿常规、生化、心电图,记录血压、心率变化,并在治疗开始及结束后检测24 h动态血压和踝臂指数。结果 8周末,两组治疗前后随机血压及24 h、白昼、夜间平均收缩压及舒张压均显著下降(P<0.05),心率无明显变化。两组降压有效率均为85%,奥美沙坦酯降压可持续24 h,收缩压及舒张压的降压谷峰比均>50%。两组治疗8周ABI较前分别有所升高(P<0.05),两组间比较差异无统计学意义(P>0.05)。结论奥美沙坦酯治疗轻中度高血压安全有效,谷峰比满意,能够24 h平稳降压,且长期应用可改善动脉硬化。

Objective To predict the effect of olmesartan medoxomil on patients with mild to moderate prima-ry hypertension and ABI. Methods A randomized trial was performed. 120 patients with mild to moderate primary hy-pertension in our hospital from July to November in 2011 were randomly divided into olmesartan group and amlodipine group. The changes of blood pressure, heart rate, electrocardiogram, blood and urinary laboratory examination were ob- served. The 24 h ambulatory blood pressure monitoring and ABI were investigated. Results After 8 week-treatment, CBP, mean systolic blood pressure （SBP） and mean diastolic blood pressure （DBP） of 24 h, daytime and night, were sig- nificantly reduced（ P 〈 0. 05 ）, while no significant difference was found in heart rate. The total effective rate of the two groups was 85%. The antihypertensive effect of olmesartan could cover over 24 h. The trough to peak ratios for systolic and diastolic blood pressure by olmesartan were all more than 50%. ABI was improved in the two groups. There was no significant difference between the two groups （ P 〉 0. 05 ）. Conclusion OlmesarWal is safe and effective for the treat-ment of mild to moderate hypertension, and the trough to peak ratio is satisfied. The effect of olmesartan once daily can maintain for 24 h. Using olmesartan longer can improve artheriosclerosis.