大剂量沐舒坦治疗老年慢性阻塞性肺疾病急性发作期的疗效

Effects of high-dose mucosolvin on acute exacerbation of chronic obstructive pulmonary disease in elderly patients

目的探讨大剂量沐舒坦(盐酸氨溴索)治疗老年慢性阻塞性肺疾病急性发作期的临床疗效及不良反应。方法选取2012年1月至2013年1月于本院进行治疗的60例慢性阻塞性肺疾病急性发作期的患者为研究对象,将其随机分为大剂量组和常规剂量组各30例,两组患者均给予控制感染、祛痰镇咳、解痉平喘及对症处理等常规治疗。大剂量组在常规治疗的基础上加用沐舒坦150 mg+0.9%氯化钠注射液250 mL,2次/d,常规剂量组在常规治疗的基础上加用沐舒坦30 mg+0.9%氯化钠注射液100 mL,2次/d,疗程7～10 d。结果大剂量组显效率76.70%、总有效率93.33%,常规剂量组显效率56.67%、总有效率83.33%,两组比较差异具有统计学意义(P<0.05)。两组患者治疗期间均未出现明显的不良反应,临床用药安全。结论大剂量沐舒坦有显著的排痰作用,联合常规抗炎平喘等治疗慢性支气管炎急性发作疗效确切且用药安全。

Objective To investigate the clinical effects and adverse effects of high-d0se mucosolvin on acute exacerbation of chronic obstructive pulmonary disease in elderly patients. Methods Sixty patients who suffered acute exacerbation of chronic obstructive pulmonary disease in our hospital from January 2012 to January 2013 were divided into high-dose group and conventional-dose group randomly. All the patients were given common treatments such as an-tibiotics, antitussive and expectorant, relieving spasm and asthma while patients in high-dose group were added muco-solvin 150 mg and 0. 9 % sodium chloride injection 250 mL 2 times per day, and those in conventional-dose group were added mucosolvin 30 mg and 0. 9% sodium chloride injection 100 mL 2 times per day for 7 - 10 days. Results In the high-dose group, the efficiency rate was 76. 70% and the total efficiency rate was 93.33% , and in the conventional- dose group,the efficiency rate was 56. 67% and the total efficiency rate was 83.33%. There were significant differ-ences between the two groups （ P 〈 0. 05 ）. There was no obvious adverse effects in the two groups. Conclusion The high-dose mucosolvin has efficacy and safety on acute exacerbation of chronic obstructive pulmonary disease in elderly patients.