YKL-40和VEGF在尖锐湿疣组织中的表达及意义

Expression and significance of YKL-40 and VEGF in condyloma acuminatum tissues

目的探讨人类软骨糖蛋白-39和血管内皮细胞生长因子在尖锐湿疣组织中的表达及意义。方法采用免疫组化SP法检测33例尖锐湿疣组织和10例正常包皮组织中YKL-40和VEGF的表达。结果尖锐湿疣组织中YKL-40和VEGF阳性强度多在(■)～(■),正常对照组多在(-)～(+),两种蛋白表达阳性强度分别和正常对照组比较差异均有统计学意义(P<0.05),但两种蛋白表达的相关性(r=0.27,P>0.05)及在不同临床因素的表达差异无统计学意义(P>0.05)。结论尖锐湿疣组织中存在YKL-40和VEGF过表达,YKL-40和VEGF的过表达可能对尖锐湿疣的发生发展有一定作用。

Objective To explore the expression of YKI. 40 and vascular endothelial cell growth factor （VEGF） in eondyloma aeuminatum （CA） tissues and the related significance. Methods The expressions of YKL-40 and VEGF were analyzed by immunocytochemical staining with streptavidin-peroxidase （SP） in 33 CA tissues and 10 foreskin tissues of normal person. Results The expression intensities of YKL 40 and VEGF varied largely from positive （＋＋） to strongly positive （＋＋＋） in CA tissues compared with negative （--） and positive （＋） in normal foreskin tissues. The expressions of YKL-40 and VEGF proteins in CA tissues were significantly different from those in the normal human controls（P^0.05）. No correlation was found between the expression of YKL 40 and VEGF proteins in CA tissues （r=0. 27, P〉0. 05）, and their expressions were not correlated with other clinical factors （P〉0.05）. Conclusion YKL-40 and VEGF are over-expressed in CA tissues, which may play a part in the occurrence and development of CA.