颈动脉结构功能改变与脑梗死的关系

Changes of the structure and function of carotid artery in cerebral infarction patients

目的:研究颈动脉结构、功能的改变与脑梗死的关系。方法:选择脑梗死患者56例及正常人50例,测量颈动脉内-中膜(IMT)厚度、颈总动脉舒张期和收缩期的内径,并计算反映颈动脉功能的颈动脉扩张性和僵硬度指数。结果:脑梗死患者比健康老年人斑块数目及低回声斑块检出率增加,平均IMT增厚(P<0.05),收缩期内径和舒张期内径增大(P<0.05)。脑梗死患者动脉扩张性明显降低于对照组(P<0.001),僵硬度指数明显增加(P<0.001)。结论:IMT厚度、颈动脉斑块可反映颈动脉结构与功能的改变,颈动脉僵硬度增加和扩张性降低可能是脑卒中早期的预报因子。

Objective.. To investigate the relationship between the structure and function of carotid artery and cerebral infarc- tion. Methods： 56 patients with cerebral infarction and 50 controls were enrolled into this study. 2-dimentional ultrasound was used to observe the diastolic intima-media thickness （IMT）. The diameter of common carotid artery in systolic and diastolic pe- riod was measured and the carotid stiffness and distensibility were calculated. Results： The number of plaques, the incidence rate of lower-echo plaques were significantly higher in the cerebral infarction group than those in the control group（P^0. 05）. The mean IMT, systolic diameter （Ds） and diastolic diameter （Dd） were significantly larger in the cerebral infarction group than those in the control group （ P 〈0. 001）. There were lower distensibility and higher stiffness index in cerebral infarction group （ P 〈0. 001）. Conclusion.. IMT, number and echo of plaques combined with the distensibility and stiffness index can provide the characters of structure and functional changes of carotid artery. Those indices can evaluate carotid artery atheroscle- rosis and predict the event of cerebrovascular disease.