MSCT灌注成像在前列腺癌诊断中的初步研究

Primary Study of MSCT Perfusion Imaging in Diagnosis of Prostate Carcinoma

目的分析前列腺癌多层螺旋CT灌注成像的特点,探讨其在前列腺癌诊断中的初步临床应用价值.方法临床或手术病理证实的前列腺癌34例,前列腺增生65例,行病变中心层面灌注扫描,得到各组PF、PEI、TTP、BV值和TDC曲线,并对各组灌注值进行对比分析.结果 PC各灌注参数的平均值:PF为(32.5±10.86)mL/(min.mg)、PEI为(27.43±10.49)HU、TTP为(22.4±3.29)s、BV为(523.11±257.38)mL/g.与BPH组比较差异有统计学意义(P<0.05).平均PF>21 mL/(min.mg)PC组数量多于平均PF<21 mL/(min.mg)组,平均TTP<25 s PC组数量明显多于平均TTP>25 s组,差异具有统计学意义(P<0.05).结论 PC组呈现高灌注、早期强化特点;PF、TTP可以提供有价值的血流动力学信息,对PC的诊断及鉴别诊断具有一定的意义.

Objective To analyze MSCT perfusion imaging features of prostate carcinoma （PC） , and investigate the preliminary clinical value of MSCT perfusion imaging in PC. Methods 34 cases with PC （PC group） and 65 cases with benign prostatic hyperplasia （BPH group） diagnosed according to the results of clinical and pathological examination were carried out perfusion CT scan. All the original maps of perfusion CT scan were inputted to an outline workstation to create color perfusion maps and measure the blood flow parameters including PF, PEI, TTP, BV of prostate cortex and medulla, and TDC profile. Results In PC group, the average value of PF, PEI, TTP and BV was （32.5 ±10.86） mL/（min.mg）, （7.43± 10.49） HU, （22.4± 3.29） s and （523.11v 257.38） mL/g, respectively, which has significant difference compared with BPH group （P〈 0.001）, the cases ofPF 〉 21 mJ（min.mg） and TIP 〈 25 s was greater than that ofPF 〈 21 mL/（min.mg） and TTP 〉 25 s in PC group respectively, and the difference was statistically significant. Conclusion The PC group exhibits the features of high perfusion and early intensity. PF and TTP values can provide valuable hemodynamic information, and it has certain significance in the PC. diagnosis and differential diagnosis.