宫颈癌新辅助化疗效果临床和病理评估结果比较

Comparison of Clinical and Pathologic Assessments for the Effect of Neoadjuvant Chemotherapy on Cervical Cancer

目的比较临床和病理评估宫颈癌新辅助化疗效果差异,探讨临床评估宫颈癌新辅助化疗效果的可行性.方法收集2010年6月至2011年12月云南省肿瘤医院Ib-IIb宫颈癌患者21例,新辅助化疗1～3个疗程后行宫颈癌根治术,术前临床评估化疗效果、术后病理评估化疗效果,比较临床评估和病理评估结果有无差异.结果临床评估新辅助化疗有效率为47.6%,病理评估有效率为42.9%,二者差异无统计学意义(P>0.05).结论临床和病理评估宫颈癌新辅助化疗疗效结果相似,临床评估可在化疗过程中实时监测化疗效果,方便、可行.

Objective This study was purposed to investigate the feasibility of clinical assessment for the effect of neoadjuvant chemotherapy in patients, according to the difference of clinical and pathologic assessments for the effect of neoadjuvant chemotherapy on cervical cancer. Methods 21 patients with cervical cancer Ib- 11 b stage in Tumor Hospital of Yunnan from June 2010 to December 2011 were treated with neoadjuvant chemotherapy for 1-3 courses of treatments. The effect of neoadjuvant chemotherapy was evaluated by the clinical assessment before the surgical operation and by the pathologic assessment after the surgical operation, and the results were compared. Results The effective rate was 47.6% and 42.9% with the clinical and pathologic assessment respectively. There was no significant difference between them （P 〉 0.05） . Conclusion The results of the clinical and pathologic assessment were similar. The clinical assessment can evaluate the effect of chemotherapy during the treatment, which was convenient and available.