雌激素受体在骨生长、代谢及其力学响应中的作用和机制

The role and mechanism of estrogen receptor in bone growth, metabolism and mechano-responsiveness

力学信号在骨组织的生长、重建和疾病治疗中发挥着重要的作用。近年来的研究发现雌激素受体(estrogenreceptor,ER)能介导雌激素效应调节骨组织细胞的增殖、凋亡以及功能活性,从而影响骨形成和骨吸收,在骨组织生长、骨重建中发挥重要作用;同时参与骨组织及其细胞对力学刺激的响应过程。骨组织响应力学刺激的效应要受到ER数量和(或)功能活性的影响。这些研究提示了力学刺激和雌激素可能通过一些共同的信号通路来调节骨组织细胞的功能活性。本文着重关注ER在骨组织及其力学响应中的作用和机制。

Mechanical signaling plays a critical role in bone growth, remodeling and healing. Recent studies dis- cover that estrogen can modulate proliferation, apoptosis and functional activity of bone cell tissues via estrogen receptor （ER） and affect bone formation and absorption. Thus ER plays an important role in bone growth and re- modeling. ER also involves in the adaptive response to mechanical stimulation, which is affected by ER numbers and activity. These findings suggest that mechanical stimulation and estrogen can act together to regulate func- tions of bone cells via common signaling pathways. In this review, the role and mechanism of ER in bone tissues and its respons to mechanical stimulation are discussed.